Multi-arm PEG Derivatives

JenKem Commercial Scale PEG productionJenKem Technology provides high quality activated multi-arm polyethylene glycol derivatives (PEGs) with high purity and low polydispersity.

JenKem Technology’s multi-arm PEG derivatives can be cross-linked into hydrogels. PEG hydrogels have a variety of applications in medical devices and regenerative medicine, and are especially of interest for controlled release of drugs, for 3D cell culture, and for wound sealing and healing [1]. JenKem Technology’s multi-arm star PEGs are synthesized by ethoxylation of tripentaerythritol (JenKem patented 8ARM(TP) PEG), hexaglycerol (8ARM PEG), dipentaerythritol (6ARM PEG), pentaerythritol (4ARM PEG), or glycerol (3ARM PEG). The number of ethylene oxide units in the PEG chain may not be equal for all arms. The total molecular weight reported for the JenKem multi-arm PEGs is the sum of the molecular weights of the PEG chains on each arm.

Multi-arm star PEG products with molecular weights and functional groups not listed in our online catalog may be available by custom synthesis. Please inquire at tech@jenkemusa.com about pricing and availability. For global distribution, please visit link. To order directly from JenKem Technology:

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3ARM PEG DERIVATIVES
3ARM PEG PRODUCT SUBSTITUTION REACTIVITY DETAILS
3ARM-PEG-NH2 ≥ 95% 3arm PEG Amine. Hydrogel PEG. Amine group binds to carboxylic group (-COOH) or other amine reactive chemical groups
4ARM PEG DERIVATIVES
4ARM PEG PRODUCT SUBSTITUTION REACTIVITY DETAILS
4ARM-PEG-NH2(pentaerythritol core) ≥ 95% 4arm PEG Amine, Free Amine. Hydrogel PEG. Amine group binds to carboxylic group (-COOH) or other amine reactive chemical groups [2, 5, 8]
4ARM-PEG-NH2HCl(pentaerythritol core) ≥ 95% 4arm PEG Amine, HCl Salt. Hydrogel PEG. Amine group binds to carboxylic group (-COOH) or other amine reactive chemical groups [2-6]
4ARM-PEG-CM (pentaerythritol core) ≥ 95% 4arm PEG Carboxyl (4arm PEG Acetic Acid, 4arm-COOH, 4arm-CM). Hydrogel PEG. Carboxyl group binds to amino or other acid reactive chemical groups [7]
4ARM-PEG-SCM (pentaerythritol core) ≥ 95% 4arm PEG SCM (4arm PEG NHS Ester). Hydrogel PEG. This is the activated form of 4ARM-COOH. [8, 9]
4ARM-PEG-SGA (pentaerythritol core) ≥ 95% 4arm PEG Succinimidyl Glutaramide. Hydrogel PEG. SGA has a longer hydrolysis half-life compared with SCM [23].
4ARM-PEG-NPC (pentaerythritol core) ≥ 95% 4arm PEG Nitrophenyl Carbonate. Hydrogel PEG. Carbonate linker between PEG and NHS ester; the reaction with amine groups releases p-nitrophenol which can be easily traced by UV spectroscopy.
4ARM-PEG-SC (pentaerythritol core) > 90% 4arm PEG Succinimidyl Carbonate. Hydrogel PEG. Carbonate linker between PEG and NHS ester; longer hydrolysis half-life compared with SCM
4ARM-PEG-MAL (pentaerythritol core) > 90% 4arm PEG Maleimide. Hydrogel PEG. Maleimide is selective for thiol groups and reacts at pH 5.0-6.5. [24-27]
4ARM-PEG-ACLT (pentaerythritol core) ≥ 95% 4arm PEG Acrylate. Hydrogel PEG. Used in vinyl polymerization or co-polymerization [10]
4ARM-PEG-SH (pentaerythritol core) > 90% 4arm PEG Thiol. Hydrogel PEG. Selective for thiol groups under mild reaction conditions [11]
4ARM-PEG-VS(pentaerythritol core) > 90% 4arm PEG Vinylsulfone. Hydrogel PEG. VS binds free thiol groups in aqueous buffer between pH 6.5~8.5 at room temperature [12]
4ARM-PEG-SS (pentaerythritol core) ≥ 95% 4arm PEG Succinimidyl Succinate. Hydrogel PEG. Cleavable PEG linker. The ester linker between PEG and NHS ester enables the feature of “degradable hydrogel”. [28]
4ARM-PEG-SG (pentaerythritol core) ≥ 95% 4arm PEG Succinimidyl Glutarate. Hydrogel PEG. Cleavable PEG linker. The ester linker between PEG and NHS ester enables the feature of “degradable hydrogel” [13].
4ARM-PEG-NCO (pentaerythritol core) > 90% 4arm PEG Isocianate. Hydrogel PEG. NCO group is useful for coupling hydroxyl through a stable urethane linker
4ARM-PEG-AZIDE (pentaerythritol core) ≥ 95% 4arm PEG Azide. Hydrogel PEG. Azide group reacts with alkynes in aqueous solution catalyzed by copper [14]
4ARM PEG RAW MATERIALS (4ARM PEG HYDROXYL)
4ARM PEG RAW MATERIALS MAIN PEAK FRACTION BY GPC POLYDISPERSITY BY GPC
4ARM-PEG MW 2000 Da, 5000Da, 15kDa, 10kDa, 20kDa ≥ 95% ≤ 1.05
6ARM PEG DERIVATIVES
6ARM PEG PRODUCT SUBSTITUTION REACTIVITY DETAILS
6ARM(DP)-PEG-NH2
(dipentaerythritol core)
≥ 95% 6arm PEG Amine. Crosslinks into hydrogels. Amine group reacts with carboxylic group (-COOH) or other amine reactive chemical groups [15]
6ARM PEG RAW MATERIALS (6ARM PEG HYDROXYL)
6ARM PEG RAW MATERIALS MAIN PEAK FRACTION BY GPC POLYDISPERSITY BY GPC
6ARM-PEG MW 15kDa, 30kDa ≥ 95% ≤ 1.08
 8ARM PEG DERIVATIVES WITH TRIPENTAERYTHRITOL CORE
8ARM PEG PRODUCT SUBSTITUTION REACTIVITY DETAILS
8ARM(TP)-PEG-NH2HCl
(tripentaerythritol core)
≥ 95% 8arm PEG Amine. Crosslinks into hydrogels. Amine group reacts with carboxylic group (-COOH) or other amine reactive chemical groups . 8ARM(TP)-PEG with tripentaerythritol core has a lower polydispersity and higher molecular weight accuracy compared with the generic 8ARM-PEG with a hexaglycerol core.[16]
8ARM(TP)-PEG-CM
(tripentaerythritol core)
≥ 95% 8arm PEG Carboxyl. Crosslinks into hydrogels. Carboxyl group reacts with amino or other acid reactive chemical groups. 8ARM(TP)-PEG with tripentaerythritol core has a lower polydispersity and higher molecular weight accuracy compared with the generic 8ARM-PEG with a hexaglycerol core. [29-31]
8ARM(TP)-PEG-MAL
(tripentaerythritol core)
> 90% 8arm PEG Maleimide. Crosslinks into hydrogels. MAL is selective for thiol groups on cystein side chains; reacts at pH 5.0-6.5. 8ARM(TP)-PEG with tripentaerythritol core has a lower polydispersity and higher molecular weight accuracy compared with the generic 8ARM-PEG with a hexaglycerin core. [32]
8ARM(TP)-PEG-ACLT  (tripentaerythritol core) ≥ 95% 8arm PEG Acrylate. Crosslinks into hydrogels. Used in vinyl polymerization or co-polymerization. 8ARM(TP)-PEG with tripentaerythritol core has a lower polydispersity and higher molecular weight accuracy compared with the generic 8ARM-PEG with a hexaglycerol core. [33]
8ARM(TP)-PEG-SH
(tripentaerythritol core)
> 90% 8arm PEG Thiol. Crosslinks into hydrogels. Selective for thiol groups under mild reaction conditions. 8ARM(TP)-PEG with tripentaerythritol core has a lower polydispersity and higher molecular weight accuracy compared with the generic 8ARM-PEG with a hexaglycerol core. [34, 35]
8ARM(TP)-PEG-VS
(tripentaerythritol core)
> 90% 8arm PEG Vinylsulfone. Crosslinks into hydrogels. VS reacts with free thiol groups in aqueous buffer between pH 6.5~8.5 at room temperature. 8ARM(TP)-PEG with tripentaerythritol core has a lower polydispersity and higher molecular weight accuracy compared with the generic 8ARM-PEG with a hexaglycerol core. [36-38]
8ARM(TP)-PEG-SS
(tripentaerythritol core)
≥ 95% 8arm PEG Succinimidyl Succinate. Crosslinks into hydrogels. Cleavable PEG linker. The ester linker between PEG and NHS ester facilitates the formation of degradable hydrogel. 8ARM(TP)-PEG with tripentaerythritol core has a lower polydispersity and higher molecular weight accuracy compared with the generic 8ARM-PEG with a hexaglycerol core. [39]
8ARM(TP)-PEG-SG
(tripentaerythritol core)
≥ 95% 8arm PEG Succinimidyl Glutarate. Crosslinks into hydrogels. Cleavable PEG linker. The ester linker between PEG and NHS ester facilitates the formation of degradable hydrogel. 8ARM(TP)-PEG with tripentaerythritol core has a lower polydispersity and higher molecular weight accuracy compared with the generic 8ARM-PEG with a hexaglycerol core. [40]
8ARM(TP)-PEG-NB
(tripentaerythritol core)
> 85% 8arm PEG Norbornene. Crosslinks into hydrogels. Norbornene NB PEGs are suitable for copper-free click chemistry reactions with tetrazines and for thiol-ene click reactions with thiols. 8ARM(TP)-PEG with tripentaerythritol core has a lower polydispersity and higher molecular weight accuracy compared with the generic 8ARM-PEG with a hexaglycerol core. [41-44]
8ARM PEG DERIVATIVES WITH HEXAGLYCEROL CORE
8ARM PEG PRODUCT SUBSTITUTION REACTIVITY DETAILS
8ARM-PEG-NH2HCl
(hexaglycerol core)
≥ 95% 8arm PEG Amine. Crosslinks into hydrogels. Amine group reacts with carboxylic group (-COOH) or other amine reactive chemical groups [16-18]
8ARM-PEG-CM
(hexaglycerol core)
≥ 95% 8arm PEG Carboxyl. Crosslinks into hydrogels. Carboxyl group binds amino or other acid reactive chemical groups [16]
8ARM-PEG-MAL
(hexaglycerol core)
> 90% 8arm PEG Maleimide. Crosslinks into hydrogels. MAL group is selective for thiol groups; reacts at pH 5.0-6.5.[19].
8ARM-PEG-ACLT
(hexaglycerol core)
≥ 95% 8arm PEG Acrylate. Crosslinks into hydrogels. Used in vinyl polymerization or co-polymerization [20]
8ARM-PEG-SH
(hexaglycerol core)
> 90% 8arm PEG Thiol. Crosslinks into hydrogels. Selective for thiol groups under mild reaction conditions [21]
8ARM-PEG-SS
(hexaglycerol core)
≥ 95% 8arm PEG Succinimidyl Succinate. Crosslinks into hydrogels. Cleavable PEG linker. The ester linker between PEG and NHS ester facilitates the formation of degradable hydrogel. Binds to amino group of lysine(s) or N-terminal amines [39, 45]
8ARM-PEG-SG
(hexaglycerol core)
≥ 95% 8arm PEG Succinimidyl Glutarate. Crosslinks into hydrogels. Cleavable PEG linker. The ester linker between PEG and NHS ester facilitates the formation of degradable hydrogel [22]
8ARM PEG RAW MATERIALS (8ARM PEG HYDROXYL)
8ARM PEG RAW MATERIALS MAIN PEAK FRACTION BY GPC POLYDISPERSITY BY GPC
8ARM(TP)-PEG MW 10kDa, 15kDa, 20kDa, 40kDa ≥ 95%(> 90% for MW 40000 Da TP core) ≤ 1.08 (TP core) (≤ 1.12 (hexaglycerol core))
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Founded in 2001 by recognized experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to on-site manufacturing from ethylene oxide, enabling facile traceability for GMP regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale
.