Activated PEGs for C-Terminal PEGylation

JenKem Technology manufactures high quality PEG derivatives for Carboxyl PEGylation, from non-GMP small laboratory scale, to commercial scale in GMP and non-GMP grade. Amine functionalized PEGs are the most employed PEG reagents for C-terminus PEGylation proteins and peptides. PEGylation of carboxyl groups with PEG amines requires the presence of coupling agents, such as water-soluble EDC, with or without NHS, for aqueous PEGylation at pH 7.2 [1-4]; or water-insoluble DCC, for non-aqueous carboxyl PEGylation reactions [5].

Activated PEG products for C-terminal PEGylation with molecular weights, branching, and functional groups not listed in our online catalog may be available by custom synthesis. Please inquire at about pricing and availability of custom PEGs for Carboxyl PEGylation.
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Y-shape PEG Amine
Y-shape PEG Amine

Methoxy PEG Amine
Methoxy PEG Amine
Monodisperse Methoxy PEG Amine

Homobifunctional diAmine PEGs
Amine PEG Amine
Monodisperse Amine PEG Amine

Heterobifunctional PEGs Functionalized with Protected Amine and Amine
Heterobifunctional PEGs Functionalized with Protected Amine
Heterobifunctional PEGs Functionalized with Amine

Multiarm Homofunctional PEGs Functionalized with Amine:
multiarm homofunctional PEGs

Multiarm Heterobifunctional PEGs Functionalized with Amine and Protected Amine:
multiarm heterobifunctional PEGs

1. Dao, T.P.T., et al., A new formulation of curcumin using poly(lactic-co-glycolic acid)—polyethylene glycol diblock copolymer as carrier material, Adv. Nat. Sci. Nanosci. Nanotechnol 2014: 5 035013 (7pp)
2. Gyudo Lee, Real-Time Quantitative Monitoring of Specific Peptide Cleavage by a Proteinase for Cancer Diagnosis, Angew. Chem. Int. Ed. 2012, 51, 5837 –5841
3. Zhang, Ti, et al., In vivo photoacoustic imaging of breast cancer tumor with HER2-targeted nanodiamonds, Proc Soc Photo Opt Instrum Eng. 2013; 8815
4. Lin Dai, Novel Multiarm Polyethylene glycol-Dihydroartemisinin Conjugates Enhancing Therapeutic Efficacy in Non-Small-Cell Lung Cancer, Scientific Reports 2014, 4 : 5871
5. York, A.W., Kinetically Assembled Nanoparticles of Bioactive Macromolecules Exhibit Enhanced Stability and Cell-Targeted Biological Efficacy, Adv. Mater. 2012, 24: 733–739. DOI: 10.1002/adma.201103348


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