Activated PEGs for C-Terminal PEGylation

JenKem Technology manufactures high quality PEG derivatives for Carboxyl PEGylation, from non-GMP small laboratory scale, to commercial scale in GMP and non-GMP grade. Amine functionalized PEGs are the most employed PEG reagents for C-terminus PEGylation proteins and peptides. PEGylation of carboxyl groups with PEG amines requires the presence of coupling agents, such as water-soluble EDC, with or without NHS, for aqueous PEGylation at pH 7.2 [1-4]; or water-insoluble DCC, for non-aqueous carboxyl PEGylation reactions [5].

Activated PEG products for C-terminal PEGylation with molecular weights, branching, and functional groups not listed in our online catalog may be available by custom synthesis. Please inquire at tech@jenkemusa.com about pricing and availability of custom PEGs for Carboxyl PEGylation.

Y-shape PEG Amine

Methoxy PEG Amine

Homobifunctional diAmine PEGs

Heterobifunctional PEGs Functionalized with Protected Amine and Amine


Multiarm Homofunctional PEGs Functionalized with Amine:

Multiarm Heterobifunctional PEGs Functionalized with Amine and Protected Amine:


References:

1. Dao, T.P.T., et al., A new formulation of curcumin using poly(lactic-co-glycolic acid)—polyethylene glycol diblock copolymer as carrier material, Adv. Nat. Sci. Nanosci. Nanotechnol 2014: 5 035013 (7pp)
2. Gyudo Lee, Real-Time Quantitative Monitoring of Specific Peptide Cleavage by a Proteinase for Cancer Diagnosis, Angew. Chem. Int. Ed. 2012, 51, 5837 –5841
3. Zhang, Ti, et al., In vivo photoacoustic imaging of breast cancer tumor with HER2-targeted nanodiamonds, Proc Soc Photo Opt Instrum Eng. 2013; 8815
4. Lin Dai, Novel Multiarm Polyethylene glycol-Dihydroartemisinin Conjugates Enhancing Therapeutic Efficacy in Non-Small-Cell Lung Cancer, Scientific Reports 2014, 4 : 5871
5. York, A.W., Kinetically Assembled Nanoparticles of Bioactive Macromolecules Exhibit Enhanced Stability and Cell-Targeted Biological Efficacy, Adv. Mater. 2012, 24: 733–739. DOI: 10.1002/adma.201103348

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