PEGs-for-ADCsJenKem Technology provides high purity monodisperse PEG raw materials and monodisperse PEG derivatives with an extensive variety of functional groups, from gram to 15 kilogram batch size or larger in both non-GMP and GMP grade. JenKem Technology’s monodisperse PEG products consist of linear chains of up to 108 –CH2-CH2-O– units (MW ~ 5000Da).

JenKem Technology’s monodisperse PEG products are produced via very reproducible chemical reactions and lack the polydispersity of traditional PEG polymers. The majority of our high quality monodisperse (discrete) PEG products have purity >98% with <1% highest single impurity.

JenKem Technology provides GMP grade discrete PEG derivatives via custom synthesis, offering the opportunity to match customers’ special quality requirements. The company is ISO 9001 and ISO 13485 certified and follows ICH Q7 guidelines for GMP manufacture.

JenKem Technology offers many monodisperse PEG linkers for antibody drug conjugated (ADCs) and PEG linkers for PROTAC drugs with high purity, in large commercial scale, in both GMP and non-GMP grade.

PEG Linkers for ADCs

Product Name Molecular Weight
NH2-PEG2-PA 177.2
NH2-PEG3-PA 221.3
NH2-PEG4-PA 265.3
NH2-PEG6-PA 353.4
NH2-PEG7-PA 397.5
NH2-PEG8-PA 441.5
NH2-PEG9-PA 485.6
NH2-PEG10-PA 529.6
NH2-PEG11-PA 573.7
NH2-PEG12-PA 617.7
NH2-PEG24-PA 1146.4
NH2-PEG8-CM 427.5
NH2-PEG12-CM 603.7
NH2-PEG24-CM 1132.3
DBCO-PEG2-PA 464.5
DBCO-PEG3-PA 508.6
DBCO-PEG4-PA 552.6
DBCO-PEG6-PA 640.7
DBCO-PEG8-PA 728.8
DBCO-PEG10-PA 816.9
DBCO-PEG12-PA 905.0
DBCO-PEG24-PA 1433.7
DBCO-PEG8-CM 714.8
DBCO-PEG12-CM 891.0
DBCO-PEG24-CM 1419.7
DBCO-PEG8-NH2 655.8
DBCO-PEG12-NH2 832.0
DBCO-PEG24-NH2 1360.6
MAL-PEG2-PA 328.3
MAL-PEG3-PA 372.4
MAL-PEG4-PA 416.4
MAL-PEG6-PA 504.5
MAL-PEG8-PA 592.6
MAL-PEG12-PA 768.9
MAL-PEG24-PA 1297.5
MAL-PEG2-SPA 425.4
MAL-PEG4-SPA 513.5
MAL-PEG6-SPA 601.6
MAL-PEG8-SPA 689.7
MAL-PEG12-SPA 865.9
MAL-PEG24-SPA 1394.6
MAL-PEG8-CM 578.6
MAL-PEG12-CM 754.8
MAL-PEG24-CM 1283.5
AZIDE-PEG4-NH2 218.3
AZIDE-PEG12-NH2 570.7
AZIDE-PEG24-NH2 1099.3
AZIDE-PEG4-PA 291.3
AZIDE-PEG12-PA 643.7
AZIDE-PEG24-PA 1172.4
AZIDE-PEG12-CM 629.7
AZIDE-PEG24-CM 1158.3
ALKYNE-PEG8-SPA 577.6
ALKYNE-PEG12-SPA 753.8
HO-PEG4-ALKYNE 232.3
DBCO-PEG4-VC-PAB 914.1
DBCO-PEG6-VC-PAB 1002.2
DBCO-PEG8-VC-PAB 1090.3
DBCO-PEG12-VC-PAB 1266.5
DBCO-PEG24-VC-PAB 1795.1
DBCO-PEG4-VA-PAB 828.0
DBCO-PEG6-VA-PAB 916.1
DBCO-PEG8-VA-PAB 1004.2
DBCO-PEG12-VA-PAB 1180.4
DBCO-PEG24-VA-PAB 1709.0
MAL-PEG4-VC-PAB 777.9
MAL-PEG6-VC-PAB 866.0
MAL-PEG8-VC-PAB 954.1
MAL-PEG12-VC-PAB 1130.3
MAL-PEG24-VC-PAB 1658.9
MAL-PEG4-VA-PAB 691.8
MAL-PEG6-VA-PAB 779.9
MAL-PEG8-VA-PAB 868.0
MAL-PEG12-VA-PAB 1044.2
MAL-PEG24-VA-PAB 1572.8

Please contact us to inquire about our large-scale manufacture capabilities for these PEGs for ADCs.

PEG Linkers for PROTAC Applications

Product Name CAS No.
Amino-PEG2-Propionic Acid 791028-27-8
Amino-PEG3-Propionic Acid 784105-33-5
Amino-PEG4-Propionic Acid 663921-15-1
Amino-PEG2-Acetic Acid 134978-97-5
Amino-PEG3-Acetic Acid 134978-99-7
Amino-PEG4-Acetic Acid 195071-49-9
Amino-PEG4-Alcohol 86770-74-3
Azido-PEG3-Alcohol 86520-52-7
Azido-PEG3-Acetic Acid 172531-37-2
Azido-PEG4-Propionic Acid 1257063-35-6
Propargyl-PEG6-Propionic Acid 1951438-84-8
Propargyl-PEG5-Amine 1589522-46-2
Bis-PEG6-Acid 119189-70-7

Please contact us to inquire about our large-scale manufacture capabilities for these PEG linkers for PROTACs.

E3 Ligase Ligand-Linker Conjugates

(S,R,S)-AHPC-PEG2-acid2172820-09-4

Product Name CAS No.
(S,R,S)-AHPC-PEG4-acid 2172820-12-9
(S,R,S)-AHPC-PEG6-acid
(S,R,S)-AHPC-PEG2-NH2 hydrochloride 2010159-60-9
(S,R,S)-AHPC-PEG4-NH2 hydrochloride 2010159-57-4
(S,R,S)-AHPC-PEG4-azide
(S,R,S)-AHPC-PEG6-alkyne
Thalidomide-O-PEG4-acid 2353563-50-3
Thalidomide-O-PEG4-NHS ester 2411681-88-2
Thalidomide-O-PEG4-t-butyl ester 2411681-87-1
Thalidomide-O-PEG4-amine 2401832-00-4
Thalidomide-O-PEG4-azide 2380318-57-8
Thalidomide-O-amido-PEG4-azide 2411681-89-3
Thalidomide-O-PEG4-propargyl 2098799-77-8
Thalidomide-O-amido-PEG4-propargyl 2411681-90-6
Pomalidomide-PEG3-acid
Pomalidomide-PEG4-Ph-NH2 1818885-63-0
Pomalidomide-PEG4-azide 2271036-47-4

Please contact us to inquire about our large-scale manufacture capabilities for these E3 Ligase Ligands and E3 Ligase Ligand-Linker Conjugates.

Below are some examples of in-stock non-GMP grade monodisperse (discrete) PEG raw materials with high purity (>99%).

Item Number Item Description
HO-PEG7-OH Heptaethylene Glycol, MW 326.4
HO-PEG8-OH Octaethylene Glycol, MW 370.4
HO-PEG9-OH Enneethylene Glycol, MW 414.5
HO-PEG10-OH Decaethylene Glycol, MW 458.6
HO-PEG11-OH Undecaethylene Glycol, MW 502.6
HO-PEG12-OH Dodecaethylene glycol, MW 546.7

Below are some examples of our monodisperse (discrete) PEG products with purity >98% that have been scaled-up to kilogram scale batch size:

Item Number Item Description
HO-PEG9-OH Enneethylene Glycol, MW 414.5
HO-PEG10-OH Decaethylene Glycol, MW 458.6
HO-PEG11-OH Undecaethylene Glycol, MW 502.6
HO-PEG12-OH Dodecaethylene glycol, MW 546.7
HO-PEG36-OH Hexatriacontaethylene Glycol, MW 1603.9
M-PEG7-OH Methoxy PEG7 Hydroxyl, MW 340.4
M-PEG11-OH Methoxy PEG11 Hydroxyl, MW 516.6
M-PEG11-PA Methoxy PEG11 Propionic Acid, MW 588.7
Bn-PEG3-OH Triethylene glycol monobenzyl ether, MW 240.3
Bn-PEG4-OH Tetraethylene glycol monobenzyl ether, MW 284.4 Da
Bn-PEG6-OH Benzyl PEG6 Hydroxyl, MW 372.5 Da
Bn-PEG7-OH Benzyl PEG7 Hydroxyl, MW 416.5Da

Please click the buttons below to order catalog items directly from JenKem Technology. Monodisperse PEG products with molecular weights and functional groups not listed in our online catalog may be available by custom synthesis. For inquiries on custom production of monodisperse PEG derivatives and PEGylation services please contact us at tech@jenkemusa.com. For global distributor information, please visit this link.

MONODISPERSE PEG PRODUCTS MW PURITY
Various > 98%
252.2 ≥ 95%
296.2 ≥95%
251.4 ≥95%
295.3 ≥95%
324.4 ≥95%
368.2 ≥95%
277.3 ≥90%
321.4 ≥90%
268.4 ≥90%
312.4 ≥90%
306.3 ≥90%
350.4 ≥90%
370.5 ≥95%
414.5 ≥95%
546.7 ≥95%
368.5 ≥95%
544.8 ≥95%
486.5 ≥95%
662.7 ≥95%
514.6 ≥95%
674.8 ≥95%
369.5 ≥95%
545.8 ≥95%
428.5 ≥95%
604.8 ≥95%
442.5 ≥95%
618.8 ≥95%

References:

  1. El-Gogary, R.I., et al., Polyethylene Glycol Conjugated Polymeric Nanocapsules for Targeted Delivery of Quercetin to Folate-Expressing Cancer Cells in Vitro and in Vivo. ACS Nano, 2014, 8(2): p. 1384-1401.
  2. Zhou, J., et al., In vivo evaluation of medical device-associated inflammation using a macrophage-specific positron emission tomography (PET) imaging probe. Bioorganic & Medicinal Chemistry Letters, 2013, 23(7): p. 2044-2047.
  3. Raza, A., et al., Influence of PEGylated porous silicon nanoparticles on permeation and efflux of an orally administered antibiotic. Materials Today Advances, 2022, 13, p.100210.

Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7 guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.