8arm PEG Succinimidyl Glutarate (hexaglycerol core) reagent with superior quality specification of ≥ 95% Substitution.
JenKem Technology’s 8arm PEG Succinimidyl Glutarate (hexaglycerol) derivatives can be crosslinked into degradable PEG hydrogels. 8arm PEG Succinimidyl Glutarate (hexaglycerol) is a cleavable PEG linker. The cleavable ester linker between PEG and NHS ester enables the feature of “degradable” hydrogels. PEG hydrogels have a variety of applications in medical devices and regenerative medicine, and are especially of interest for controlled release of drugs, for 2D and 3D cell culture, and for wound sealing and healing. JenKem Technology’s 8 arm PEGs are synthesized by ethoxylation of tripentaerythritol (8ARM PEG(TP)) or hexaglycerol (8ARM PEG). The number of ethylene oxide units in the PEG chain may not be equal for all arms. The total molecular weight reported for the JenKem multi-arm PEGs is the sum of the PEG molecular weights of each arm.
JenKem Technology also provides 8ARM(TP)-PEG hydroxyl raw materials and PEG derivatives with tripentaerythritol core. 8ARM(TP)-PEGs with tripentaerythritol core have a higher purity as evidenced by MALDI compared with the generic 8ARM-PEGs with a hexaglycerin core.
Multi-arm star PEG products with molecular weights, branching, and functional groups not listed in our online catalog may be available by custom synthesis. Please inquire at email@example.com about pricing and availability.
Bulk PEGs and GMP PEGs are made-to-order. Please contact us for special bulk pricing.
1. Kaphle, P., et al., The mechanical and pharmacological regulation of glioblastoma cell migration in 3D matrices, Journal of cellular physiology, 2019, 234(4):3948-60.
2. Tong, X., et al., Engineering interpenetrating network hydrogels as biomimetic cell niche with independently tunable biochemical and mechanical properties. Biomaterials, 2014, 35(6): p. 1807-1815.
3. Sargeant, T.D., et al., An in situ forming collagen–PEG hydrogel for tissue regeneration. Acta Biomaterialia, 2012, 8(1): p. 124-132.
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Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.