JenKem Technology provides high purity activated heterobifunctional PEGs for Antibody-Drug Conjugates (ADCs). Incorporation of PEG linkers between the antibody and payload can influence the properties1 of the ADCs.PEG Linkers for ADCs

– Modulate the physicochemical properties, such as balance the payloads’ hydrophobicity, improve solubility, increase DAR, and reduce aggregation
– Modify the Pharmacodynamic properties, such as increase the rate of payload release and increase invitro cytotoxicity
– Optimize the pharmacokinetic properties, such as clearance, half-life, and biodistribution

JenKem Technology provides a variety of PEG linkers to help with your ADC-related projects. JenKem Technology’s patented multi-arm heterofunctional PEG derivatives are designed as linkers for ADCs, as they facilitate the coupling of high ratios of drug molecules per antibody, thus increasing Drug-to-antibody ratio (DAR). Examples include but are not limited to 4ARM-PEG-(NH2)3-COOH, 4ARM-PEG-(MAL)3-NHS, 8ARM-PEG-(NH2)7-COOH, or 8ARM-PEG-(MAL)7-NHS. Read more on https://www.jenkemusa.com/multi-arm-bifunctional-pegs-for-adcs about these innovative PEG derivatives.

Additionally, JenKem Technology offers many monodisperse PEG linkers for ADCs with high purity, in large commercial scale, in both GMP and non-GMP grade, some examples listed below.

Monodisperse PEG Products for ADCs

Molecular Weight

NH2-PEG2-PA
177.2
NH2-PEG3-PA

221.3

NH2-PEG4-PA

265.3

NH2-PEG6-PA
353.4
NH2-PEG7-PA

397.5

NH2-PEG8-PA

441.5

NH2-PEG9-PA

485.6

NH2-PEG10-PA
529.6
NH2-PEG11-PA
573.7
NH2-PEG12-PA

617.7

NH2-PEG24-PA

1146.4

NH2-PEG8-CM

427.5

NH2-PEG12-CM
603.7
NH2-PEG24-CM
1132.3
DBCO-PEG2-PA

464.5

DBCO-PEG3-PA

508.6

DBCO-PEG4-PA
552.6
DBCO-PEG6-PA
640.7
DBCO-PEG8-PA

728.8

DBCO-PEG10-PA

816.9

DBCO-PEG12-PA
905.0
DBCO-PEG24-PA

1433.7

DBCO-PEG8-CM

714.8

DBCO-PEG12-CM
891.0
DBCO-PEG24-CM
1419.7
DBCO-PEG8-NH2

655.8

DBCO-PEG12-NH2

832.0

DBCO-PEG24-NH2

1360.6

MAL-PEG2-PA
328.3
MAL-PEG3-PA

372.4

MAL-PEG4-PA
416.4
MAL-PEG6-PA

504.5

MAL-PEG8-PA
592.6
MAL-PEG12-PA

768.9

MAL-PEG24-PA

1297.5

MAL-PEG2-SPA
425.4
MAL-PEG4-SPA
513.5
MAL-PEG6-SPA

601.6

MAL-PEG8-SPA

689.7

MAL-PEG12-SPA

865.9

MAL-PEG24-SPA
1394.6
MAL-PEG8-CM
578.6
MAL-PEG12-CM

754.8

MAL-PEG24-CM

1283.5

AZIDE-PEG4-NH2
218.3
AZIDE-PEG12-NH2
570.7
AZIDE-PEG24-NH2

1099.3

AZIDE-PEG4-PA

291.3

AZIDE-PEG12-PA

643.7

AZIDE-PEG24-PA
1172.4
AZIDE-PEG12-CM
629.7
AZIDE-PEG24-CM

1158.3

ALKYNE-PEG8-SPA

577.6

ALKYNE-PEG12-SPA
753.8
HO-PEG4-ALKYNE
232.3
DBCO-PEG4-VC-PAB

914.1

DBCO-PEG6-VC-PAB

1002.2

DBCO-PEG8-VC-PAB

1090.3

DBCO-PEG12-VC-PAB
1266.5
DBCO-PEG24-VC-PAB
1795.1
DBCO-PEG4-VA-PAB

828.0

DBCO-PEG6-VA-PAB

916.1

DBCO-PEG8-VA-PAB
1004.2
DBCO-PEG12-VA-PAB
1180.4
DBCO-PEG24-VA-PAB
1709.0
MAL-PEG4-VC-PAB

777.9

MAL-PEG6-VC-PAB

866.0

MAL-PEG8-VC-PAB

954.1

MAL-PEG12-VC-PAB
1130.3
MAL-PEG24-VC-PAB

1658.9

MAL-PEG4-VA-PAB

691.8

MAL-PEG6-VA-PAB
779.9
MAL-PEG8-VA-PAB
868.0
MAL-PEG12-VA-PAB

1044.2

MAL-PEG24-VA-PAB

1572.8

Please contact us to inquire about our large-scale manufacture capabilities for these PEGs for ADCs.

1 Giese, M. W., Woodman, R. H., Hermanson, G. T. & Davis, P. D. in Chemical Linkers in Antibody-Drug Conjugates (ADCs) 286-376 (The Royal Society of Chemistry, 2022).

Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7 guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.