JenKem Technology provides high purity activated heterobifunctional PEGs for Antibody-Drug Conjugates (ADCs). Incorporation of PEG linkers between the antibody and payload can influence the properties1 of the ADCs.
– Modulate the physicochemical properties, such as balance the payloads’ hydrophobicity, improve solubility, increase DAR, and reduce aggregation
– Modify the Pharmacodynamic properties, such as increase the rate of payload release and increase invitro cytotoxicity
– Optimize the pharmacokinetic properties, such as clearance, half-life, and biodistribution
JenKem Technology provides a variety of PEG linkers to help with your ADC-related projects. JenKem Technology’s patented multi-arm heterofunctional PEG derivatives are designed as linkers for ADCs, as they facilitate the coupling of high ratios of drug molecules per antibody, thus increasing Drug-to-antibody ratio (DAR). Examples include but are not limited to 4ARM-PEG-(NH2)3-COOH, 4ARM-PEG-(MAL)3-NHS, 8ARM-PEG-(NH2)7-COOH, or 8ARM-PEG-(MAL)7-NHS. Read more on https://www.jenkemusa.com/multi-arm-bifunctional-pegs-for-adcs about these innovative PEG derivatives.
Additionally, JenKem Technology offers many monodisperse PEG linkers for ADCs with high purity, in large commercial scale, in both GMP and non-GMP grade, some examples listed below.
Please contact us to inquire about our large-scale manufacture capabilities for these PEGs for ADCs.
1 Giese, M. W., Woodman, R. H., Hermanson, G. T. & Davis, P. D. in Chemical Linkers in Antibody-Drug Conjugates (ADCs) 286-376 (The Royal Society of Chemistry, 2022).
Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7 guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.