JenKem Technology provides high quality polyethylene glycol (PEG) derivatives for C-terminal PEGylation with high purity and low polydispersity, from non-GMP laboratory scale, to large commercial scale in GMP and non-GMP grade.JenKem Beijing R&D Amine functionalized PEGs are the most utilized PEG reagents for C-terminus PEGylation proteins and peptides. PEGylation of carboxyl groups with PEG amines requires the presence of coupling agents, such as water-soluble EDC, with or without NHS, for aqueous PEGylation at pH 7.2 [1-4]; or water-insoluble DCC, for non-aqueous carboxyl PEGylation reactions [5].

JenKem Technology manufactures linear and branched multi-arm amine functionalized PEGs, either homofunctional and heterobifunctional. The sterically bulky structure of JenKem Technology’s proprietary Y-shape branched PEG derivatives, consisting of two linear methoxy PEG chains attached to a central core with an active amine group, may help to reduce the number of attachment sites to a protein molecule.

Activated PEG products for C-terminal PEGylation with molecular weights, branching, and functional groups not listed in our online catalog may be available by custom synthesis. Please inquire at about pricing and availability of custom PEGs for Carboxyl PEGylation, and PEGylation services.

JenKem Technology provides GMP grade PEG derivatives and bulk orders via custom synthesis, offering the opportunity to match customers’ special quality requirements. JenKem Technology is capable of development and synthesis of a wide range of GMP PEG derivatives in 200g to 40 kg or greater batches, under ISO 9001 and ISO 13485 certified quality management system, following ICH Q7A guidelines. In 2020 JenKem Technology will transition to use High Purity (> 99%) mPEG Raw Materials to manufacture all GMP grade Methoxy PEG Derivatives. For inquiries on cGMP production of PEG derivatives please contact us at

For global distribution, please visit link. Click the buttons below to order directly from JenKem Technology:

Y-shape PEG Amine
≥ 95% Y-shape PEG Amine, more reactive towards acylating agents than the hydroxyl group; readily undergoes reductive amination reactions. JenKem proprietary Y-shape PEGs are more selective, due to their sterically bulky structure. [6]
Methoxy PEG Amine
≥ 95% Methoxy PEG Amine. Attaches via stable linkages, such as amide, urethane, urea, secondary amine; the HCl salt form provides stability for the solid form of M-PEG-NH2 [7, 19, 22-26]
≥ 95% Monodisperse Methoxy PEG5 Amine and Methoxy PEG6 Amine. Attaches via stable linkages, such as amide, urethane, urea, secondary amine. JenKem Technology’s monodisperse PEG products are produced via very reproducible chemical reactions and lack the polydispersity of traditional PEG polymers.
Homobifunctional Amine PEGs
≥ 95% Amine PEG Amine (PEG diamine). PEG Crosslinker, attaches via stable linkages, such as amide, urethane, urea, secondary amines. [8-18]
≥ 95% Monodisperse Amine PEG8 Amine or Amine PEG12 Amine (Discrete PEG bisamine). PEG Crosslinker, attaches via stable linkages, such as amide, urethane, urea, secondary amines. JenKem Technology’s monodisperse PEG products are produced via very reproducible chemical reactions and lack the polydispersity of traditional PEG polymers. [20, 21]
Heterobifunctional Amine Functionalized PEGs:
Multiarm Homofunctional PEGs Functionalized with Amine:
Multiarm Heterobifunctional PEGs Functionalized with Amine and Protected Amine:


  1. Dao, T.P.T., et al., A new formulation of curcumin using poly(lactic-co-glycolic acid)—polyethylene glycol diblock copolymer as carrier material, Adv. Nat. Sci. Nanosci. Nanotechnol, 2014, 5, 035013.
  2. Gyudo Lee, Real-Time Quantitative Monitoring of Specific Peptide Cleavage by a Proteinase for Cancer Diagnosis, Angew. Chem. Int. Ed., 2012, 51, 5837 –5841.
  3. Zhang, Ti, et al., In vivo photoacoustic imaging of breast cancer tumor with HER2-targeted nanodiamonds, Proc Soc Photo Opt Instrum Eng., 2013, 8815.
  4. Lin Dai, Novel Multiarm Polyethylene glycol-Dihydroartemisinin Conjugates Enhancing Therapeutic Efficacy in Non-Small-Cell Lung Cancer, Scientific Reports, 2014, 4 : 5871.
  5. York, A.W., Kinetically Assembled Nanoparticles of Bioactive Macromolecules Exhibit Enhanced Stability and Cell-Targeted Biological Efficacy, Adv. Mater., 2012, 24: 733–739.
  6. Amoozgar, Z., et al., Dual-layer surface coating of PLGA-based nanoparticles provides slow-release drug delivery to achieve metronomic therapy in a paclitaxel-resistant murine ovarian cancer model, Biomacromolecules, 2014, 15(11):4187-94.
  7. Duan, H., et al., A novel electrospun nanofiber system with PEGylated paclitaxel nanocrystals enhancing the transmucus permeability and in situ retention for an efficient cervicovaginal cancer therapy, International Journal of Pharmaceutics, 650, 2024.
  8. Zhang, T., et al., Magnetic/pH dual-responsive nanocomposites loading doxorubicin hydrochloride for cancer therapy, Micro & Nano Letters, 2019.
  9.  Jain, S., et al., Estradiol functionalized multi-walled carbon nanotubes as renovated strategy for efficient gene delivery, RSC Advances, 2016, 6(13):10792-801.
  10. Mou, J., et al., A New Green Titania with Enhanced NIR Absorption for Mitochondria-Targeted Cancer Therapy, Theranostics, 2017, 7(6):1531-1542.
  11. Chen, N., et al., Cy5.5 conjugated MnO nanoparticles for magnetic resonance/near-infrared fluorescence dual-modal imaging of brain gliomas, Journal of Colloid and Interface Science, 2015, V. 457, P. 27-34.
  12. Liu, S., et al., Meter-long multiblock copolymer microfibers via interfacial bioorthogonal polymerization, Adv. Mater., 2015.
  13. Zhang, T., et al., Targeted nanodiamonds as phenotype-specific photoacoustic contrast agents for breast cancer, Nanomedicine, 2015, V. 10:4 , P. 573-587.
  14. Cheng, L., et al., Construction and evaluation of PAMAM–DOX conjugates with superior tumor recognition and intracellular acid-triggered drug release properties, Colloids and Surfaces B: Biointerfaces, 2015, V. 136, P 37-45.
  15. Li, S., et al., Targeted imaging of brain gliomas using multifunctional Fe3O4/MnO nanoparticles, RSC Adv., 2015, 5, 33639-33645.
  16. Chen, W., et al., Assembly of Fe3O4 nanoparticles on PEG-functionalized graphene oxide for efficient magnetic imaging and drug delivery, RSC Adv., 2015, 5, 69307-69311.
  17. Yu, H., et al., Polyvinylpyrrolidone functionalization induces deformable structure of graphene oxide nanosheets for lung-targeting delivery, Nano Today, 2021, V. 38.
  18. Liao, H. T., et al, A bioactive multi-functional heparin-grafted aligned poly(lactide-co-glycolide)/curcumin nanofiber membrane to accelerate diabetic wound healing, Materials Science and Engineering: C, 2021, V. 120.
  19. Li, Z., et al., Self-sterilizing diblock polycation-enhanced polyamidoxime shape-stable blow-spun nanofibers for high-performance uranium capture from seawater, Chemical Engineering Journal, 2020, V. 390.
  20. El-Gogary, R.I., et al., Polyethylene Glycol Conjugated Polymeric Nanocapsules for Targeted Delivery of Quercetin to Folate-Expressing Cancer Cells in Vitro and in Vivo. ACS Nano, 2014, 8(2), p. 1384-1401.
  21. Zhou, J., et al., In vivo evaluation of medical device-associated inflammation using a macrophage-specific positron emission tomography (PET) imaging probe, Bioorganic & Medicinal Chemistry Letters, 2013, 23(7): p. 2044-2047.
  22. Xia, C., et al., Redox-responsive nanoassembly restrained myeloid-derived suppressor cells recruitment through autophagy-involved lactate dehydrogenase A silencing for enhanced cancer immunochemotherapy, Journal of Controlled Release, 2021, V. 335, P. 557-574.
  23. Lv, F., et al., Enhanced mucosal penetration and efficient inhibition efficacy against cervical cancer of PEGylated docetaxel nanocrystals by TAT modification, Journal of Controlled Release, 2021, V. 336, P. 572-582.
  24. Doan, T.N., et al., Endothelin-1 Inhibits Size Dependent Lymphatic Clearance of PEG-Based Conjugates After Intra-Articular Injection into the Rat Knee, Acta biomaterialia, 2019.
  25. Xia, S., et al., Role of poly (ethylene glycol) grafted silica nanoparticle shape in toughened PLA-matrix nanocomposites, Composites Part B: Engineering, 2019.
  26. Babity, S., et al., Data on the removal of peroxides from functionalized polyethylene glycol (PEG) and effects on the stability and sensitivity of resulting PEGylated conjugates, Data in Brief, 2020:106258.

Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.