PEG Raw Materials

JenKem Technology manufactures high quality polyethylene glycol (PEG) raw materials with high purity and low polydispersity. In-house PEG production is back-integrated to the ethylene oxide starting material. JenKem Technology ‘s hydroxyl PEG raw materials (PEG alcohols) are suitable for further derivatization into PEG derivatives. JenKem® PEG raw materials are sold in bulk without purification after polymerization. Please contact us at for inquiries on the availability of purified or research grade PEG raw materials.

JenKem Technology provides high quality linear polyethylene glycol hydroxyl raw materials with high purity, low polydispersity, and low to no diol content. Linear monofunctional methoxy PEG raw materials are end-capped with a methoxy group or benzyl group. Linear Methoxy PEG Hydroxyl raw materials are provided as bulk orders of 1kg or more, with the molecular weights of 5kDa, 10kDa, 20kDa, 30kDa, and 40kDa.  JenKem Technology also provides a GPC Calibration Standard kit  for linear methoxy PEGs (STDMPEG) containing 200mg each of linear PEGs with MW of 2kDa, 5kDa, 10kDa, 20kDa and 40kDa.

JenKem Technology now provides JenKem patented 8ARM(TP)-PEG hydroxyl raw materials with tripentaerythritol core. 8ARM(TP)-PEGs with tripentaerythritol core have a lower polydispersity and higher molecular weight accuracy compared with the generic 8ARM-PEGs with a hexaglycerin core.

The molecular weight of JenKem Technology’s multi-arm PEG hydroxyl raw materials is the sum of the molecular weights of all of the arms. Each arm may have different lengths. 4ARM-PEG-OH (4arm PEG hydroxyl) is prepared by ethoxylation of pentaerythritol. 6ARM-PEG-OH (6arm PEG hydroxyl) is prepared by ethoxylation of dipentaerythritol. 8ARM-PEG-OH (8arm PEG hydroxyl) is prepared either by ethoxylation of tripentaerythritol (TP), or hexaglycerol. JenKem Technology also provides a 4ARM PEG GPC Calibration Standards kit (STD4ARMPEG) that includes 200 mg each of 4ARM-PEG-2000, 4ARM-PEG-5000, 4ARM-PEG-10K, 4ARM-PEG-20K, and 4ARM-PEG-40K.

JenKem Technology’s hydroxyl PEG raw materials with molecular weights not listed in our online catalog may be available by custom synthesis. Please inquire at about pricing and availability. For global distribution, please visit link. To order directly from JenKem Technology:

M-PEG 5kDa, 10kDa, 20kDa, 30kDa, 40kDa ≥ 95% ≤ 1.05-1.10 [2-4]
BENZYL-PEG 2kDa, 5kDa ≥ 95% ≤ 1.05 [5]
4ARM-PEG 2kDa, 5kDa, 15kDa, 10kDa, 20kDa ≥ 95% ≤ 1.05 [6-19]
6ARM-PEG 15kDa, 30kDa ≥ 95% ≤ 1.08 [20]
8ARM(TP)-PEG 10kDa, 15kDa, 20kDa, 40kDa ≥ 95%; > 90% for MW 40,000 ≤ 1.08 [21-25]
8ARM-PEG 10kDa, 15kDa, 20kDa, 40kDa ≥ 95% ≤ 1.12 [26-32]


  1. Hutanu, D., et al., Recent Applications of Polyethylene Glycols (PEGs) and PEG Derivatives. Mod Chem appl 2014. 2(132).
  2. Long, T., et al., Covalent Immobilization of Enoxacin onto Titanium Implant Surfaces for Inhibiting Multiple Bacterial Species Infection and In Vivo Methicillin-Resistant Staphylococcus aureus Infection Prophylaxis. Antimicrobial Agents and Chemotherapy. 2017; 61(1):e01766-16..
  3. Long, T., et al., Covalent Immobilization of Enoxacin onto Titanium Implant Surfaces for Inhibiting Multiple Bacterial Species Infection and In Vivo Methicillin-Resistant Staphylococcus aureus Infection Prophylaxis, Antimicrobial Agents and Chemotherapy, 2017, 61(1) :e01766-16.
  4. Mu, J., et al., Highly stable and biocompatible W18O49@PEG-PCL hybrid nanospheres combining CT imaging and cancer photothermal therapy, RSC Advances, 2017, 7(18):10692-9.
  5. Mueller, C., et al., Noncovalent PEGylation: Different Effects of Dansyl-, l-Tryptophan–, Phenylbutylamino-, Benzyl- and Cholesteryl-PEGs on the Aggregation of Salmon Calcitonin and Lysozyme, Journal of Pharmaceutical Sciences, 2012, Volume 101 , Issue 6 , p. 1995 – 2008.
  6. Lee, S., et al., Fabrication of schizophyllan hydrogel via orthogonal thiol-ene photopolymerization, Carbohydrate Polymers, 2017.
  7. Belair, D.G., et al., Regulating VEGF signaling in platelet concentrates via specific VEGF sequestering, Biomaterials Science, 2016.
  8. Belair, D.G., et al., Differential Regulation of Angiogenesis using Degradable VEGF-Binding Microspheres. Biomaterials, 2016.
  9. Croitoru-Sadger, T., et al., A flexible polymersome system with tunable morphology and release profiles for efficient intracellular delivery, International Journal of Pharmaceutics, 2016, 508, 1–2, p: 34-41.
  10. Munoz-Pinto, D.J., et al., Impact of secondary reactive species on the apparent decoupling of poly(ethylene glycol) diacrylate hydrogel average mesh size and modulus, Polymer, 2015, Volume 77, Pages 227-238.
  11. Shih, H., et al., Photo-click hydrogels prepared from functionalized cyclodextrin and poly(ethylene glycol) for drug delivery and in situ cell encapsulation, Biomacromolecules, 2015, 16 (7), pp 1915–1923.
  12. Truong, V.X., et al., Simultaneous Orthogonal Dual-Click Approach to Tough, in-Situ Forming Hydrogels for Cell Encapsulation, J. Am. Chem. Soc., 2015, 137, 1618−1622.
  13. Li, Q., et al., Controlling Hydrogel Mechanics via Bio-Inspired Polymer–Nanoparticle Bond Dynamics, ACS Nano, 2015, DOI: 10.1021/acsnano.5b06692.
  14. Kessler, M., et al., Application of Linear and Branched Poly(Ethylene Glycol)-Poly(Lactide) Block Copolymers for the Preparation of Films and Solution Electrospun Meshes. Macromol. Biosci. 2015.
  15. Zhou, C., et al., Antibacterial poly(ethylene glycol) hydrogels from combined epoxy-amine and thiol-ene click reaction. J. Polym. Sci. Part A: Polym. Chem. 2015.
  16. Shubin, A.D., et al., Development of Poly(Ethylene Glycol) Hydrogels for Salivary Gland Tissue Engineering Applications, Tissue Engineering Part A., 2015, 21(11-12): 1733-1751.
  17. Lin, T.-Y., et al., Designing Visible Light-Cured Thiol-Acrylate Hydrogels for Studying the HIPPO Pathway Activation in Hepatocellular Carcinoma Cells. Macromol. Biosci., 2015.
  18. Greene, T., et al., Modular Cross-Linking of Gelatin-Based Thiol–Norbornene Hydrogels for in Vitro 3D Culture of Hepatocellular Carcinoma Cells, ACS Biomaterials Science & Engineering, 2015, 1 (12), 1314-1323.
  19. Kaya, N.U., et al., Multifunctional Dendrimer Formation Using Thiolactone Chemistry, Macromolecular Chemistry and Physics, 2017..
  20. Liu, Y., Design Of Robust Hydrogel Based On Mussel-Inspired Chemistry, Michigan Technological University, 2017.
  21. Dias, A.D., et al., Microcarriers with Synthetic Hydrogel Surfaces for Stem Cell Expansion, Advanced Healthcare Materials, 2017.
  22. Parlato, M., et al., Specific Recruitment of Circulating Angiogenic Cells Using Biomaterials as Filters, Acta Biomaterialia, 2017.
  23. Usprech, J., et al., Combinatorial screening of 3D biomaterial properties that promote myofibrogenesis for mesenchymal stromal cell-based heart valve tissue engineering, Acta Biomaterialia, 2017.
  24. Neumann , A.J., et al., Nondestructive evaluation of a new hydrolytically degradable and photo-clickable PEG hydrogel for cartilage tissue engineering. Acta biomaterialia. 2016.
  25. Boere, K.W.M., et al, Biofabrication of reinforced 3D-scaffolds using two-component hydrogels, J. Mater. Chem. B, 2015,3, 9067-9078.
  26. Mabry, K.M., et al., Microarray analyses to quantify advantages of 2D and 3D hydrogel culture systems in maintaining the native valvular interstitial cell phenotype, Biomaterials, 2016, Volume 74, Pages 31-41.
  27. Lee, S., et al., Effects of the poly(ethylene glycol) hydrogel crosslinking mechanism on protein release, Biomater. Sci., 2016, DOI: 10.1039/C5BM00256G.
  28. Belair, D.G., et al., Human iPSC-derived endothelial cell sprouting assay in synthetic hydrogel arrays. Acta biomaterialia. 2016.
  29. Manzoli, V., et al., Engineering human renal epithelial cells for transplantation in regenerative medicine, Medical Engineering & Physics, 2017.
  30. Wang, C., et al., Effect of matrix metalloproteinase‐mediated matrix degradation on glioblastoma cell behavior in 3D PEG‐based hydrogels, Journal of Biomedical Materials Research Part A, 2017, 105(3):770-8.
  31. Shih, H., Improving gelation efficiency and cytocompatibility of visible light polymerized thiol-norbornene hydrogels via addition of soluble tyrosine, Biomaterials Science, 2017, 5(3):589-99.
  32. Buwalda, S.J., et al., Robust & thermosensitive poly (ethylene glycol)-poly (ε-caprolactone) star block copolymer hydrogels. Polymer Degradation and Stability. 2017;137:173-83.

Founded in 2001 by recognized experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to on-site manufacturing from ethylene oxide, enabling facile traceability for GMP regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.