JenKem Technology manufactures high quality polyethylene glycol (PEG) raw materials with high purity and low polydispersity. In-house PEG production is back-integrated to the ethylene oxide starting material. JenKem Technology ‘s hydroxyl PEG raw materials (PEG alcohols) are suitable for further derivatization into PEG derivatives. JenKem® PEG raw materials are sold in bulk without purification after polymerization. Please contact us at email@example.com for inquiries on the availability of purified or research grade PEG raw materials.
JenKem Technology provides high quality linear polyethylene glycol hydroxyl raw materials with high purity, low polydispersity, and low to no diol content. Linear monofunctional methoxy PEG raw materials are end-capped with a methoxy group or benzyl group. Linear Methoxy PEG Hydroxyl raw materials are provided as bulk orders of 1kg or more, with the molecular weights of 5kDa, 10kDa, 20kDa, 30kDa, and 40kDa. JenKem Technology also provides a GPC Calibration Standard kit for linear methoxy PEGs (STDMPEG) containing 200mg each of linear PEGs with MW of 2kDa, 5kDa, 10kDa, 20kDa and 40kDa.
JenKem Technology now provides proprietary 8ARM(TP)-PEG hydroxyl raw materials with tripentaerythritol core. 8ARM(TP)-PEGs with tripentaerythritol core have a higher purity as evidenced by MALDI compared with the generic 8ARM-PEGs with a hexaglycerin core.
The molecular weight of JenKem Technology’s multi-arm PEG hydroxyl raw materials is the sum of the molecular weights of all of the arms. Each arm may have different lengths. JenKem Technology’s PEG raw materials with molecular weights not listed in our online catalog may be available by custom synthesis. Please inquire at firstname.lastname@example.org about pricing and availability. For global distribution, please visit link. To order directly from JenKem Technology:
|PEG PRODUCT||AVAILABLE MOLECULAR WEIGHTS||MAIN PEAK FRACTION BY GPC||POLYDISPERSITY BY GPC||REFERENCES|
|5kDa, 10kDa, 20kDa, 30kDa, 40kDa||≥ 95%||≤ 1.05-1.10||[2-4]|
|2kDa, 5kDa||≥ 95%||≤ 1.05|||
|2kDa, 5kDa, 15kDa, 10kDa, 20kDa||≥ 95%||≤ 1.05||[6-19]|
|15kDa, 30kDa||≥ 95%||≤ 1.08|||
|10kDa, 15kDa, 20kDa, 40kDa||≥ 95%; > 90% for MW 40,000||≤ 1.08||[21-25]|
|10kDa, 15kDa, 20kDa, 40kDa||≥ 95%||≤ 1.12||[26-32]|
PEG Raw Materials for discrete PEG derivatives with ≥ 95% Purity are also available from small through large commercial scale. Please visit the following page to view a few examples and contact us if the structure you need is not listed on the link.
- Hutanu, D., et al., Recent Applications of Polyethylene Glycols (PEGs) and PEG Derivatives. Mod Chem appl 2014. 2(132).
- Long, T., et al., Covalent Immobilization of Enoxacin onto Titanium Implant Surfaces for Inhibiting Multiple Bacterial Species Infection and In Vivo Methicillin-Resistant Staphylococcus aureus Infection Prophylaxis. Antimicrobial Agents and Chemotherapy. 2017; 61(1):e01766-16..
- Jackson, M.A., et al., Zwitterionic Nanocarrier Surface Chemistry Improves siRNA Tumor Delivery and Silencing Activity Relative to Polyethylene Glycol. ACS Nano. 2017.
- Mu, J., et al., Highly stable and biocompatible W18O49@PEG-PCL hybrid nanospheres combining CT imaging and cancer photothermal therapy, RSC Advances, 2017, 7(18).
- Mueller, C., et al., Noncovalent PEGylation: Different Effects of Dansyl-, l-Tryptophan–, Phenylbutylamino-, Benzyl- and Cholesteryl-PEGs on the Aggregation of Salmon Calcitonin and Lysozyme, Journal of Pharmaceutical Sciences, 2012, Volume 101 , Issue 6 , p. 1995 – 2008.
- Lee, S., et al., Fabrication of schizophyllan hydrogel via orthogonal thiol-ene photopolymerization, Carbohydrate Polymers, 2017.
- Shagan, A., et al., Near-Infrared Light Induced Phase Transition of Biodegradable Composites for On-Demand Healing and Drug Release, ACS applied materials & interfaces 2018, 10(4), pp.4131-4139.
- Carthew, J., et al., Polyethylene glycol–gelatin hydrogels with tuneable stiffness prepared by horseradish peroxidase-activated tetrazine–norbornene ligation, Journal of Materials Chemistry B 2018, 6, no. 9.
- Yue, K., et al., Visible light crosslinkable human hair keratin hydrogels, Bioengineering & translational medicine, 2018, 3(1), pp.37-48.
- Qi, D., et al., Mechanically robust cryogels with injectability and bioprinting supportability for adipose tissue engineering, Acta Biomaterialia 2018.
- Kelbauskas, L., et al., A platform for high-throughput bioenergy production phenotype characterization in single cells, Scientific Reports, 2017, 7:45399.
- Truong, V.X., et al., Nonswelling Click-Cross-Linked Gelatin and PEG Hydrogels with Tunable Properties Using Pluronic Linkers, Biomacromolecules, 2017, 18(3):757-66.
- Truong, V.X., et al., Red Light Activation of Tetrazine–Norbornene Conjugation for Bioorthogonal Polymer Cross-Linking across Tissue, Chemistry of Materials, 2017, 29(8):3678-85.
- Tokuda, E.Y., et al., PEG–peptide hydrogels reveal differential effects of matrix microenvironmental cues on melanoma drug sensitivity. Integrative Biology. 2017.
- Vats, K., et al., Nanoscale physicochemical properties of chain‐and step‐growth polymerized PEG hydrogels affect cell‐material interactions. Journal of Biomedical Materials Research Part A. 2017.
- Kaya, N.U., et al., Multifunctional Dendrimer Formation Using Thiolactone Chemistry, Macromolecular Chemistry and Physics, 2017.
- Kelmansky, R., et al., In Situ Dual Cross-Linking of Neat Biogel with Controlled Mechanical and Delivery Properties, Molecular pharmaceutics, 2017, 14(10):3609-16.
- Liang, Y., et al., Liposome-crosslinked hybrid hydrogels for glutathione-triggered delivery of multiple cargo molecules, Biomacromolecules, 2016.
- Saghiri, M.A., et al., Hydrogel Arrays and Choroidal Neovascularization Models for Evaluation of Angiogenic Activity of Vital Pulp Therapy Biomaterials, Journal of endodontics, 2018, 44(5), pp.773-779.
- Pushparajan, C., et al., A mechanically strengthened polyacrylamide gel matrix fully compatible with electrophoresis of proteins and nucleic acids, Electrophoresis, 2018, 39(5-6), pp.824-832.
- Dias, A.D., et al., Microcarriers with Synthetic Hydrogel Surfaces for Stem Cell Expansion, Advanced Healthcare Materials, 2017.
- Parlato, M., et al., Specific Recruitment of Circulating Angiogenic Cells Using Biomaterials as Filters, Acta Biomaterialia, 2017.
- Usprech, J., et al., Combinatorial screening of 3D biomaterial properties that promote myofibrogenesis for mesenchymal stromal cell-based heart valve tissue engineering, Acta Biomaterialia, 2017.
- Pinnaratip, R., et al., Effect of incorporating clustered silica nanoparticles on the performance and biocompatibility of catechol-containing PEG-based bioadhesive. Biomedical Materials, 2018, 13(2), p.025003
- Gregoritza, M., et al., Fabrication of antibody-loaded microgels using microfluidics and thiol-ene photoclick chemistry, European Journal of Pharmaceutics and Biopharmaceutics, 2018, 127, pp.194-203.
- Buwalda, S.J., et al., Robust & thermosensitive poly (ethylene glycol)-poly (ε-caprolactone) star block copolymer hydrogels. Polymer Degradation and Stability. 2017;137:173-83.
- Manzoli, V., et al., Engineering human renal epithelial cells for transplantation in regenerative medicine, Medical Engineering & Physics, 2017.
- Wang, C., et al., Effect of matrix metalloproteinase‐mediated matrix degradation on glioblastoma cell behavior in 3D PEG‐based hydrogels, Journal of Biomedical Materials Research Part A, 2017, 105(3):770-8.
- Shih, H., Improving gelation efficiency and cytocompatibility of visible light polymerized thiol-norbornene hydrogels via addition of soluble tyrosine, Biomaterials Science, 2017, 5(3):589-99.
- Mabry, K.M., et al., Microarray analyses to quantify advantages of 2D and 3D hydrogel culture systems in maintaining the native valvular interstitial cell phenotype, Biomaterials, 2016, Volume 74, Pages 31-41.
Founded in 2001 by recognized experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to on-site manufacturing from ethylene oxide, enabling facile traceability for GMP regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.