JenKem Technology manufactures high quality polyethylene glycol raw materials with high purity and low polydispersity. JenKem Technology’s in-house PEG production is back-integrated to the ethylene oxide starting material. JenKem Technology’s PEG alcohols are suitable for further derivatization into PEG derivatives.
Linear PEG Raw Materials
JenKem Technology provides high quality linear methoxy and benzyl polyethylene glycol raw materials with high purity, low polydispersity, and low to no diol content. These PEG raw materials are end-capped with a methoxy group or benzyl group. Linear PEG raw materials are provided as bulk orders of 100g or more, with the molecular weights of 5kDa, 10kDa, 20kDa, 30kDa, and 40kDa.
Starting 2020, JenKem Technology will transition to use High Purity (> 99%) mPEG Raw Materials to manufacture GMP grade Methoxy PEG Derivatives.
JenKem Technology also provides a Methoxy PEG GPC Calibration Standards kit (STDMPEG) containing linear methoxy PEGs with MW of 2kDa, 5kDa, 10kDa, 20kDa and 40kDa.
Multi-Arm PEG Raw Materials
8ARM-PEG-OH (8arm PEG hydroxyl) is prepared either by ethoxylation of tripentaerythritol (TP core), or hexaglycerine. 8ARM(TP)-PEGs with tripentaerythritol core have a higher purity as evidenced by MALDI compared to the generic 8ARM-PEGs with a hexaglycerin core. 6ARM-PEG-OH (6arm PEG hydroxyl) is prepared by ethoxylation of dipentaerythritol. 4ARM-PEG-OH (4arm PEG hydroxyl) is prepared by ethoxylation of pentaerythritol. JenKem Technology reports the total molecular weight of multi-arm PEG raw materials as the sum of the molecular weights of all the arms. The number of ethylene oxide units in the PEG chain may not be equal for all arms.
JenKem Technology also provides a 4ARM PEG GPC Calibration Standards kit (STD4ARMPEG) that includes 200 mg each of 4ARM-PEG-2000, 4ARM-PEG-5000, 4ARM-PEG-10K, 4ARM-PEG-20K, and 4ARM-PEG-40K.
JenKem Technology’s PEG raw materials with molecular weights and branching not listed in our online catalog may be available by custom synthesis. Please inquire at firstname.lastname@example.org about pricing and availability of custom polyethylene glycols.
|PEG PRODUCT||AVAILABLE MOLECULAR WEIGHTS||MAIN PEAK FRACTION BY GPC||POLYDISPERSITY BY GPC||REFERENCES|
|5kDa, 10kDa, 20kDa, 30kDa, 40kDa||≥ 95%||≤ 1.05-1.10||[2-4]|
|2kDa, 5kDa||≥ 95%||≤ 1.05|||
|2kDa, 5kDa, 15kDa, 10kDa, 20kDa||≥ 95%||≤ 1.05||[6-19]|
|15kDa, 30kDa||≥ 95%||≤ 1.08|||
|10kDa, 15kDa, 20kDa, 40kDa||≥ 95%; > 90% for MW 40,000||≤ 1.08||[21-25]|
|10kDa, 15kDa, 20kDa, 40kDa||≥ 95%||≤ 1.12||[26-30]|
PEG Raw Materials for discrete PEG derivatives with purity ≥ 95% are also available from small through large commercial scale. Please visit the following page to view a few examples and contact us if the structure you need is not listed on the link:
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Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.