PEG Raw Materials

JenKem Technology manufactures high quality polyethylene glycol (PEG) raw materials with high purity and low polydispersity. In-house PEG production is back-integrated to the ethylene oxide starting material. JenKem Technology ‘s hydroxyl PEG raw materials (PEG alcohols) are suitable for further derivatization into PEG derivatives. JenKem® PEG raw materials are sold in bulk without purification after polymerization. Please contact us at tech@jenkemusa.com for inquiries on the availability of purified or research grade PEG raw materials.

JenKem Technology provides high quality linear polyethylene glycol hydroxyl raw materials with high purity, low polydispersity, and low to no diol content. Linear monofunctional methoxy PEG raw materials are end-capped with a methoxy group or benzyl group. Linear Methoxy PEG Hydroxyl raw materials are provided as bulk orders of 1kg or more, with the molecular weights of 5kDa, 10kDa, 20kDa, 30kDa, and 40kDa.  JenKem Technology also provides a GPC Calibration Standard kit  for linear methoxy PEGs (STDMPEG) containing 200mg each of linear PEGs with MW of 2kDa, 5kDa, 10kDa, 20kDa and 40kDa.

JenKem Technology now provides JenKem patented 8ARM(TP)-PEG hydroxyl raw materials with tripentaerythritol core. 8ARM(TP)-PEGs with tripentaerythritol core have a lower polydispersity and higher molecular weight accuracy compared with the generic 8ARM-PEGs with a hexaglycerin core.

8armPEGs
The molecular weight of JenKem Technology’s multi-arm PEG hydroxyl raw materials is the sum of the molecular weights of all of the arms. Each arm may have different lengths. 4ARM-PEG-OH (4arm PEG hydroxyl) is prepared by ethoxylation of pentaerythritol. 6ARM-PEG-OH (6arm PEG hydroxyl) is prepared by ethoxylation of dipentaerythritol. 8ARM-PEG-OH (8arm PEG hydroxyl) is prepared either by ethoxylation of tripentaerythritol (TP), or hexaglycerol. JenKem Technology also provides a 4ARM PEG GPC Calibration Standards kit (STD4ARMPEG) that includes 200 mg each of 4ARM-PEG-2000, 4ARM-PEG-5000, 4ARM-PEG-10K, 4ARM-PEG-20K, and 4ARM-PEG-40K.

JenKem Technology’s hydroxyl PEG raw materials with molecular weights not listed in our online catalog may be available by custom synthesis. Please inquire at tech@jenkemusa.com about pricing and availability. For global distribution, please visit link. To order directly from JenKem Technology:

ORDER ONLINE
PEG PRODUCT AVAILABLE MOLECULAR WEIGHTS MAIN PEAK FRACTION BY GPC POLYDISPERSITY BY GPC REFERENCES
M-PEG 5kDa, 10kDa, 20kDa, 30kDa, 40kDa ≥ 95% ≤ 1.05-1.10 [2-4]
BENZYL-PEG 2kDa, 5kDa ≥ 95% ≤ 1.05 [5]
4ARM-PEG 2kDa, 5kDa, 15kDa, 10kDa, 20kDa ≥ 95% ≤ 1.05 [6-19]
6ARM-PEG 15kDa, 30kDa ≥ 95% ≤ 1.08 [20]
8ARM(TP)-PEG 10kDa, 15kDa, 20kDa, 40kDa ≥ 95%; > 90% for MW 40,000 ≤ 1.08 [21-25]
8ARM-PEG 10kDa, 15kDa, 20kDa, 40kDa ≥ 95% ≤ 1.12 [26-32]

References:

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Founded in 2001 by recognized experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to on-site manufacturing from ethylene oxide, enabling facile traceability for GMP regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.