JenKem Technology provides high quality heterobifunctional polyethylene glycol derivatives (PEGs) with high purity and low polydispersity.
JenKem Technology’s heterobifunctional PEG derivatives are generally employed as crosslinking agents or as spacers between two different chemical entities. The PEG moiety in the heterobifunctional PEG derivatives provides water solubility, biocompatibility, and flexibility to the linker. Linear heterobifunctional PEG derivatives have the following general structure:
where X and Y are two different functional reactive groups.
JenKem Technology’s multi-arm heterofunctional PEG Derivatives are also useful as linkers for Antibody-Drug Conjugates. ADCs conjugated via heterobifunctional PEGs exhibit improved water solubility and PK/PD profile.
Heterobifunctional PEG products with molecular weights and functional groups not listed in our online catalog may be available by custom synthesis. Please inquire at firstname.lastname@example.org about pricing and availability of custom heterobifunctional PEGs.
JenKem Technology provides GMP grade PEG derivatives and bulk orders via custom synthesis, offering the opportunity to match customers’ special quality requirements. JenKem Technology is capable of development and synthesis of a wide range of GMP PEG derivatives starting at 200g up to 40 kg or greater batches, under ISO 9001 and ISO 13485 certified quality management system, following ICH Q7A guidelines. For inquiries on cGMP production of PEG derivatives please contact us at email@example.com.
|PEG PRODUCT||PURITY||REACTIVITY DETAILS|
|≥95%||Hydroxyl PEG Carboxyl (Hydroxyl PEG Acetic Acid, HO-PEG-CM, HO-PEG-COOH). COOH group is stable and can be activated [1, 2, 12]|
|≥95%||Hydroxyl PEG Succinimidyl Carboxymethyl Ester (HO-PEG-NHS). Crosslinking reagent, the activated form of HO-PEG-COOH [3, 4]|
|≥95%||Hydroxyl PEG Propionic Acid (Hydroxyl PEG Propanoic Acid, HO-PEG-PA). COOH group is stable and can be activated|
|≥95%||Hydroxyl PEG Succinimidyl Propionate (Hydroxyl PEG Succinimidyl Propanoate, HO-PEG-SPA). Crosslinking reagent, the activated form of HO-PEG-PA|
|≥95%||Hydroxyl PEG Hexanoic Acid (HO-PEG-HA). COOH group is stable and can be activated|
|≥95%||Hydroxyl PEG Amine (HO-PEG-NH2). NH2 group is stable and can be activated |
|≥95%||Thiol PEG Carboxyl (HS-PEG-COOH, Thiol PEG Acetic Acid, HS-PEG-CM). HS is thiol reactive, while COOH is stable and can be activated [5, 6]|
|≥95%||Thiol PEG Succinimidyl Propionate (HS-PEG-SPA). HS is thiol reactive while COOH is stable and can be activated |
|>90%||Thiol PEG Succinimidyl Glutaramide (HS-PEG-SGA). Crosslinking PEG reagent. Longer hydrolysis half-life compared to the SCM NHS PEG ester. |
|≥95%||Thiol PEG Amine (HS-PEG-NH2). HS is thiol reactive and NH2 is stable and can be activated |
|≥95%||Amine PEG Carboxyl (NH2-PEG-COOH). Both COOH and NH2 groups are stable and can be activated [10, 11, 40, 41]|
|≥95%||TBOC Amine PEG Hydroxyl (TBOC-PEG-OH). Crosslinking PEG reagent. Tert-butyloxycarbonyl (Boc) protection group can be removed by treatment with trifluoroacetic acid (TFA) or other common acids to provide a free amine |
|≥95%||TBOC Amine PEG Amine (TBOC-PEG-NH2). Crosslinking PEG reagent. Tert-butyloxycarbonyl (Boc) protection group can be removed by treatment with trifluoroacetic acid (TFA) or other common acids to provide a free amine |
|≥95%||TBOC Amine PEG Carboxyl (TBOC-PEG-COOH, TBOC-PEG-CM, TBOC PEG Acetic Acid). Tert-butyloxycarbonyl (Boc) protection group can be removed by treatment with trifluoroacetic acid (TFA) or other common acids to provide a free amine |
|>90%||TBOC Amine PEG SCM Ester (TBOC-PEG-SCM, TBOC-PEG-NHS, ). Crosslinking PEG for ADC development. Tert-butyloxycarbonyl (Boc) protection group can be removed by treatment with trifluoroacetic acid (TFA) or other common acids to provide a free amine |
|≥95%||FMOC Amine PEG Hydroxyl (FMOC-PEG-OH) Crosslinking PEG reagent. The 9-fluorenylmethoxycarbonyl (Fmoc) group can be removed by treatment with piperidine to release a free amine |
|≥95%||FMOC Amine PEG Amine (FMOC-PEG-NH2). Crosslinking PEG reagent. 9-fluorenylmethoxycarbonyl (Fmoc) group can be removed by treatment with piperidine to release a free amine |
|≥95%||FMOC Amine PEG Carboxyl (FMOC-PEG-COOH, FMOC-PEG-CM, FMOC-PEG-Acetic Acid). The 9-fluorenylmethoxycarbonyl (Fmoc) group can be removed by treatment with piperidine to release a free amine [16, 17]|
|>90%||FMOC Amine PEG NHS Ester (FMOC-PEG-SCM, FMOC-PEG-NHS). The 9-fluorenylmethoxycarbonyl (Fmoc) group can be removed by treatment with piperidine to release a free amine |
|>90%||Acrylate PEG NHS Ester (ACLT-PEG-NHS, ACLT-PEG-SCM). Light sensitive PEG, will crosslink with exposure to ultraviolet light [20-22]|
|>90%||Acrylate PEG Succinimidyl Propionate (ACLT-PEG-SPA). Light sensitive PEG, will crosslink with exposure to ultraviolet light|
|≥95%||Maleimide PEG Hydroxyl (MAL-PEG-OH). Maleimide is thiol reactive and Hydroxyl is stable |
|≥95%||Maleimide PEG Amine (MAL-PEG-NH2). Maleimide is thiol reactive and Amine is stable and can be activated |
|≥95%||Maleimide PEG Carboxyl (MAL-PEG-CM, MAL-PEG-COOH). Maleimide is thiol reactive and Carboxyl is stable and can be activated |
|>90%||Maleimide PEG NHS Ester, the activated form of MAL-PEG-COOH [26-31]|
|>90%||Biotin PEG SCM Ester. Biotin can be attached to avidin-containing surfaces or molecules; NHS ester reacts with amine groups |
|≥95%||Biotin PEG Maleimide. Crosslinking reagent for ADC development. Biotin can be attached to avidin-containing surfaces or molecules; Maleimide group is thiol reactive |
|≥95%||Biotin PEG Succinimidyl Glutaramide. Biotin can be attached to avidin-containing surfaces or molecules; SGA has a longer hydrolysis half-life compared with SCM NHS Ester |
|>90%||OPSS PEG NHS Ester. Ortho-pyridyl disulfide (OPSS) is thiol reactive; NHS ester can be reacted with Amine groups |
|>90%||Azide PEG NHS Ester. The Azide group may be reduced to amine by hydrogenolysis; Click chemistry PEG reagent for reaction with alkynes |
|≥95%||Azide PEG Amine. The Azide group may be reduced to amine by hydrogenolysis; Click PEG reagent for reaction with alkynes |
|≥95%||Alkyne PEG Maleimide. Click PEG reagent for reaction with azides |
Monodisperse (Discrete) Heterobifunctional PEGs
Multiarm Heterobifunctional (3ARM, 4ARM, 6ARM and 8ARM PEGs)
Linear PEG Raw Materials (Methoxy PEG Hydroxyl and Benzyl PEG Hydroxyl)
|PEG RAW MATERIAL||MAIN PEAK FRACTION BY GPC||POLYDISPERSITY BY GPC|
- Abstiens, K., et al., Gold-tagged Polymeric Nanoparticles with Spatially Controlled Composition for Enhanced Detectability in Biological Environments, ACS Applied Nano Materials, 2019.
- Abstiens, K., et al., Interaction of functionalized nanoparticles with serum proteins and its impact on colloidal stability and cargo leaching, Soft matter., 2019.
- Dutta, R., et al., Pharmacokinetics and Biodistribution of GDC-0449 Loaded Micelles in Normal and Liver Fibrotic Mice, Pharmaceutical research, 2017, 34(3):564-78.
- Chen, G., et al., KE108-conjugated unimolecular micelles loaded with a novel HDAC inhibitor thailandepsin-A for targeted neuroendocrine cancer therapy, Biomaterials, 2016, 97, p. 22-33.
- Mao, W., et al., Doxorubicin encapsulated clicked gold nanoparticle clusters exhibiting tumor-specific disassembly for enhanced tumor localization and computerized tomographic imaging, Journal of Controlled Release, 2018, 269: 52-62.
- Shi, H., et al., Tumor-targeting CuS nanoparticles for multimodal imaging and guided photothermal therapy of lymph node metastasis, Acta biomaterialia, 2018, 72, pp.256-265.
- Barros, D., et al., An affinity-based approach to engineer laminin-presenting cell instructive microenvironments, Biomaterials, 2019, 192:601-11.
- Xu, Y., et al., Triphenylphosphonium-modified poly (ethylene glycol)-poly (ε-caprolactone) micelles for mitochondria-targeted gambogic acid delivery, International Journal of Pharmaceutics, 2017, 522(1):21-33.
- Feng, S., et al., Sorafenib encapsulated in nanocarrier functionalized with glypican-3 specific peptide for targeted therapy of hepatocellular carcinoma, Colloids and Surfaces B: Biointerfaces, 2019, 184.
- Wang, Z.-L., et al., Capture of Circulating Tumor Cells by Hydrogel-Nanofiber Substrate, Chinese Journal of Analytical Chemistry, 2019, 47 (8), p. 1162-1169.
- Terracciano, M., et al., In Vivo Toxicity Assessment of Hybrid Diatomite Nanovectors Using Hydra vulgaris as a Model System, Advanced Biosystems, 2019.
- Feldmann, D.P., et al., The impact of microfluidic mixing of triblock micelleplexes on in vitro in vivo gene silencing and intracellular trafficking, Nanotechnology, 2017, 28(22):224001.
- Zhang, X., et al., Inhibiting PI3 kinase-γ in both myeloid and plasma cells remodels the suppressive tumor microenvironment in desmoplastic tumors, Journal of Controlled Release, 2019, 309, p. 173-180.
- Soni, K.S., et al., Tuning polypeptide-based micellar carrier for efficient combination therapy of ErbB2-positive breast cancer, Journal of Controlled Release, 2017, V. 264, P. 276-287.
- Chen, F., et al., Glycyrrhetinic acid-decorated and reduction-sensitive micelles to enhance the bioavailability and anti-hepatocellular carcinoma efficacy of tanshinone IIA, Biomater. Sci., 2016,4, 167-182.
- Veiman, K.-L., et al., PEG shielded MMP sensitive CPPs for efficient and tumor specific gene delivery in vivo, Journal of Controlled Release, 2015, 209: 238-247.
- Guarnieri, D., et al., Tumor‐activated prodrug (TAP)‐conjugated nanoparticles with cleavable domains for safe doxorubicin delivery, Biotechnology and Bioengineering, 2015, 112(3): 601-611.
- Kuruvilla, S.P., et al., Effect of N-acetylgalactosamine ligand valency on targeting dendrimers to hepatic cancer cells, International journal of pharmaceutics, 2018, 545(1-2), pp.27-36.
- Post, A., et al., Elucidation of Endothelial Cell Hemostatic Regulation with Integrin-Targeting Hydrogels, Annals of biomedical engineering, 2019.
- Post, A., et al., Introduction of sacrificial bonds to hydrogels to increase defect tolerance during suturing of multilayer vascular grafts, Acta Biomaterialia, 2018, V. 69, p. 313-322.
- Shih, T.Y., et al., Injectable, Tough Alginate Cryogels as Cancer Vaccines, Advanced healthcare materials, 2018, p.1701469.
- Stukel, J.M., et al., The interplay of peptide affinity and scaffold stiffness on neuronal differentiation of neural stem cells. Biomedical Materials, 2018, 13(2), p.024102.
- Xu, X., et al., Efficient and targeted drug/siRNA co-delivery mediated by reversibly crosslinked polymersomes toward anti-inflammatory treatment of ulcerative colitis (UC), Nano Research, 2019, 1-9.
- Huang, Z.G., et al., RGD-modified PEGylated paclitaxel nanocrystals with enhanced stability and tumor-targeting capability, International journal of pharmaceutics, 2019, 556:217-25.
- Wu, D., et al., RGD/TAT-functionalized chitosan-graft-PEI-PEG gene nanovector for sustained delivery of NT-3 for potential application in neural regeneration, Acta biomaterialia, 2018, 72, pp.266-277.
- Säälik, P., et al., Peptide-guided nanoparticles for glioblastoma targeting, Journal of Controlled Release, 2019, 308, p. 109-118.
- Rajkumar, S., et al., Multi-functional core-shell Fe3O4@Au nanoparticles for cancer diagnosis and therapy, Colloids and Surfaces B: Biointerfaces, 2019, Vol. 174, P. 252-259.
- Liu, L., et al., Photoacoustic Therapy for Precise Eradication of Glioblastoma with a Tumor Site Blood–Brain Barrier Permeability Upregulating Nanoparticle, Advanced Functional Materials, 2019, 1808601.
- Ngamcherdtrakul, W., et al., Lanthanide-Loaded Nanoparticles as Potential Fluorescent and Mass Probes for High-Content Protein Analysis, Bioengineering, 2019, 6(1):23.
- Saqafi, B., et al., Polyethyleneimine-polyethylene glycol copolymer targeted by anti-HER2 nanobody for specific delivery of transcriptionally targeted tBid containing construct, Artificial cells, nanomedicine, and biotechnology, 2019.
- Narmani, A., et al., Synthesis and evaluation of polyethylene glycol-and folic acid-conjugated polyamidoamine G4 dendrimer as nanocarrier, Journal of Drug Delivery Science and Technology, 2019.
- Balzer, C. J., et al., Single-Turnover Activation of Arp2/3 Complex by Dip1 May Balance Nucleation of Linear versus Branched Actin Filaments, Current Biology, 2019.
- Khare, R., et al., Identification of Adenovirus Serotype 5 Hexon Regions That Interact with Scavenger Receptors, J. Virology, 2012, 86(4) p: 2293-2301.
- Wen, M., et al., Performance of TMC-g-PEG-VAPG/miRNA-145 complexes in electrospun membranes for target-regulating vascular SMCs, Colloids and Surfaces B: Biointerfaces, 2019, 182.
- Guo, Q., et al., GLUT1-mediated effective anti-miRNA21 pompon for cancer therapy, Acta Pharmaceutica Sinica B., 2019.
- Ma, H., et al., Dehydroascorbic Acid and pGPMA Dual Modified pH-Sensitive Polymeric Micelles for Target Treatment of Liver Cancer. Journal of pharmaceutical sciences, 2018, 107(2), pp.595-603.
- Badkas, A., et al., Modulation of in vitro phagocytic uptake and immunogenicity potential of modified Herceptin®-conjugated PLGA-PEG nanoparticles for drug delivery, Colloids and Surfaces B: Biointerfaces, 2018, V. 162, P. 271-278.
- Ju, L., et al., Von Willebrand factor-A1 domain binds platelet glycoprotein Ibα in multiple states with distinctive force-dependent dissociation kinetics, Thrombosis Research, 2015, V. 136:3, P. 606-612.
- Alpsoy, L., et al., Synthesis and Characterization of Carboxylated Luteolin (CL)-Functionalized SPION, Journal of Superconductivity and Novel Magnetism, 2017.
- Clawson, G.A., et al., A Cholecystokinin B Receptor-Specific DNA Aptamer for Targeting Pancreatic Ductal Adenocarcinoma, Nucleic acid therapeutics, 2017, 27(1):23-35.
- Lu, J., et al., Fabrication of thermo-and pH-sensitive cellulose nanofibrils-reinforced hydrogel with biomass nanoparticles, Carbohydrate Polymers, 2019.
- Li, H., et al., Combination of active targeting, enzyme-triggered release and fluorescent dye into gold nanoclusters for endomicroscopy-guided photothermal/photodynamic therapy to pancreatic ductal adenocarcinoma, Biomaterials, 2017.
- Stefanick, J.F., et al., Dual-receptor targeted strategy in nanoparticle design achieves tumor cell selectivity through cooperativity, Nanoscale, 2019, 11(10):4414-27.
Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.