Heterobifunctional PEGs with Protected Amine

Heterobifunctional PEG FMOC Amine and TBOC Amine from JenKem Technology are generally employed as crosslinking agents or as spacers between two different chemical entities. The 9-fluorenylmethoxycarbonyl (Fmoc) protective group can be removed by treatment with piperidine to release a free amine. Tert-butyloxycarbonyl (Boc) protection group can be removed by treatment with trifluoroacetic acid (TFA) or other common acids to provide a free amine. The PEG moiety in the heterobifunctional PEG derivatives provides water solubility, biocompatibility, and flexibility. Applications of heterobifunctional PEGs are generally geared towards the development of antibody drug conjugates (ADC’s).

Heterobifunctional FMOC Amine PEGylation products with molecular weights, branching, and functional groups not listed in our online catalog may be available by custom synthesis. Please inquire at tech@jenkemusa.com about pricing and availability of custom PEGs.

JenKem Technology provides GMP grade PEG derivatives and bulk orders via custom synthesis, offering the opportunity to match customers’ special quality requirements. JenKem Technology is capable of development and synthesis of a wide range of GMP PEG derivatives starting at 200g up to 40 kg or greater batches, under ISO 9001 and ISO 13485 certified quality management system, following ICH Q7A guidelines. For inquiries on cGMP production of PEG derivatives please contact us at tech@jenkemusa.com.

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