8arm PEG Maleimide (hexaglycerol)

$130.00$1,120.00

PEG products with additional MW may be made to order, please contact us for details

Description

8arm PEG Maleimide (hexaglycerol) with superior quality specification of > 90% Substitution.

JenKem Technology’s 8arm PEG Maleimide (hexaglycerol) HCl salt derivatives can be crosslinked into PEG hydrogels. PEG hydrogels have a variety of applications in medical devices and regenerative medicine, and are especially of interest for controlled release of drugs, for 2D and 3D cell culture, and for wound sealing and healing. JenKem Technology’s 8 arm PEGs are synthesized by ethoxylation of tripentaerythritol (8ARM PEG(TP)) or hexaglycerol (8ARM PEG). The number of ethylene oxide units in the PEG chain may not be equal for all arms. The total molecular weight reported for the JenKem multi-arm PEGs is the sum of the PEG molecular weights of each arm.

8ARM TP CORE ADVANTAGES

JenKem Technology also provides 8ARM(TP)-PEG hydroxyl raw materials and PEG derivatives with tripentaerythritol core. 8ARM(TP)-PEGs with tripentaerythritol core have a higher purity as evidenced by MALDI compared with the generic 8ARM-PEGs with a hexaglycerin core.

Multi-arm star PEG products with molecular weights, branching, and functional groups not listed in our online catalog may be available by custom synthesis. Please inquire at tech@jenkemusa.com about pricing and availability.

Bulk PEGs and GMP PEGs are made-to-order. Please contact us for bulk pricing.

References:

1. Wang, J., et al., Multi-arm PEG-maleimide conjugation intermediate characterization and hydrolysis study by a selective HPLC method, Journal of Pharmaceutical and Biomedical Analysis, 2019, V. 164, P. 452-459.

2. Dumont, C.M., et al., Aligned hydrogel tubes guide regeneration following spinal cord injury, Acta Biomaterialia, 2019.

3. Verheyen, C.A. et al., Characterization of Polyethylene Glycol–Reinforced Alginate Microcapsules for Mechanically Stable Cell Immunoisolation, Macromolecular Materials and Engineering, 2019.

4. Schweikle, M., et al., Stabilisation of amorphous calcium phosphate in polyethylene glycol hydrogels, Acta Biomaterialia, 2019.

5. Buss, C.G., et al., Protease activity sensors noninvasively classify bacterial infections and antibiotic responses, EBioMedicine, 2018, V. 38, P. 248-256.

6. Day, J.R., et al., The impact of functional groups of poly(ethylene glycol) macromers on the physical properties of photo-polymerized hydrogels and the local inflammatory response in the host, Acta Biomaterialia, 2018, V. 67, P. 42-52.

6. Villa, C., et al., Effects of Composition of Alginate-Polyethylene Glycol Microcapsules and Transplant Site on Encapsulated Islet Graft Outcomes in Mice, Transplantation, 2017, 101(5), 1025-35.

7. Darling, N.J., et al., Controlling the kinetics of thiol-maleimide Michael-type addition gelation kinetics for the generation of homogenous poly (ethylene glycol) hydrogels, Biomaterials, 2016.

8. Li, Y., et al., Non-Covalent Photo-Patterning of Gelatin Matrices Using Caged Collagen Mimetic Peptides, Macromolecular Bioscience, 2015, 15(1), 52-62.

9. Lu, H.D., et al., Injectable shear-thinning hydrogels engineered with a self-assembling Dock-and-Lock mechanism. Biomaterials, 2012, 33(7), p. 2145-2153.

Click here to download the MSDS

Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.

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