Activated PEGs for Thiol PEGylation

JenKem Technology manufactures high quality activated PEG products for thiol PEGylation, or sulfhydryl PEGylation. Methoxy PEG Maleimide is selective for thiol groups on cystein side chains of proteins. The sterically bulky Y-shape PEG Maleimide facilitate the single point attachment to thiol containing molecules.Methoxy PEG Vinylsulfone is a sulfhydryl reactive PEG that reacts at high pH. Methoxy PEG Thiol (polydisperse or monodisperse PEGs) are thiol reactive towards HS groups on cysteine side chains under mild reaction conditions.
Activated PEG products for thiol PEGylation with molecular weights, branching, and functional groups not listed in our online catalog may be available by custom synthesis. Please inquire at tech@jenkemusa.com about pricing and availability of custom PEGs for thiol PEGylation.

Y-shaped Maleimide PEGs

U-shaped Branched PEG Maleimide

Linear Maleimide PEGs

Linear Maleimide PEG PLA

Linear Vinylsulfone PEGs

Linear Thiol PEGs

Homobifunctional PEGs for Thiol PEGylation


Monodisperse PEGs Functionalized with Thiol

Heterobifunctional PEGs Functionalized with Thiol Reactive Groups

Multiarm Homofunctional PEGs Functionalized with Thiol Reactive Groups

Multiarm Heterobifunctional PEGs Functionalized with Thiol Reactive Groups