/Activated PEGs for Thiol PEGylation

Activated PEGs for Thiol PEGylation

JenKem Technology manufactures high quality activated PEG products for thiol PEGylation, or sulfhydryl PEGylation. Methoxy PEG Maleimide is selective for thiol groups on cystein side chains of proteins. The sterically bulky Y-shape PEG Maleimide facilitate the single point attachment to thiol containing molecules.Methoxy PEG Vinylsulfone is a sulfhydryl reactive PEG that reacts at high pH. Methoxy PEG Thiol (polydisperse and monodisperse) are thiol reactive towards HS groups on cysteine side chains under mild reaction conditions.

Activated PEG products for thiol PEGylation with molecular weights, branching, and functional groups not listed in our online catalog may be available by custom synthesis. Please inquire at tech@jenkemusa.com about pricing and availability of custom PEGs for thiol PEGylation.

JenKem Technology provides GMP grade PEG derivatives and bulk orders via custom synthesis, offering the opportunity to match customers’ special quality requirements. JenKem Technology is capable of development and synthesis of a wide range of GMP PEG derivatives starting at 200g up to 40 kg or greater batches, under ISO 9001 and ISO 13485 certified quality management system, following ICH Q7A guidelines. For inquiries on cGMP production of PEG derivatives please contact us at tech@jenkemusa.com.

Y-shaped Maleimide PEGs

U-shaped Branched PEG Maleimide

Linear Maleimide PEGs

Linear Maleimide PEG PLA

Linear Vinylsulfone PEGs

Linear Thiol PEGs

Homobifunctional PEGs for Thiol PEGylation


Monodisperse PEGs Functionalized with Thiol

Heterobifunctional PEGs Functionalized with Thiol Reactive Groups

Multiarm Homofunctional PEGs Functionalized with Thiol Reactive Groups

Multiarm Heterobifunctional PEGs Functionalized with Thiol Reactive Groups



Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.

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