Activated PEGs for N-terminal PEGylation

JenKem Technology’s aldehyde PEGs are reactive PEGs towards the N-terminal amine. Methoxy PEG Propionaldehyde is an N-terminal amine reactive PEG that reacts at pH 5-8 in the presence of a reducing reagent. M-ALD-20K is a PEG raw material for biosimilars of Pegfilgrastim.
Y-shape PEGs facilitate the single point attachment to N-terminal amine containing molecules, due to their sterically bulky structure. Y-shaped Propionaldehyde PEG is a reactive PEG for N-terminal amines in the presence of a reducing reagent at pH 5-8; less selective but more reactive compared with Y-AALD-40K. Y-shaped Acetaldehyde PEG is also an N-terminal amine reactive PEG in the presence of a reducing reagent at pH 5-8; less reactive but more selective compared to linear PEG aldehydes.

N-Terminal PEGylation products with molecular weights, branching, and functional groups not listed in our online catalog may be available by custom synthesis. Please inquire at tech@jenkemusa.com about pricing and availability of custom N-Terminal PEGylation products.

Y-shaped Branched Acetaldehyde PEGs

Y-shaped Branched Propionaldehyde PEGs

Linear Aldehyde PEGs

Heterobifunctional PEGs Functionalized with Propionaldehyde