Cleavable Linker PEGs

NHS PEGs with Cleavable Linker are especially useful in controlled release applications, such as in the development of Antibody Drug Conjugates / ADC products. PEG-SS and PEG-SG are double esters, having one NHS ester at the end of the polymer chain, and a second ester between PEG and the NHS group. The NHS ester at the end can couple to amines, while the ester in the middle can be cleaved under regular ester cleaving conditions. This particular feature turns them into degradable PEGs.

NHS PEGs with Cleavable Linker with molecular weights, branching, and functional groups not listed in our online catalog may be available by custom synthesis.
Other available cleavable linkers: PEG OPSS for cleavable disulfide bond formation; and PEG-oligopeptides for enzymatic cleavage. PEG products with disulfide S-S linkers are also available by custom synthesis. Please inquire at about pricing and availability of custom PEGylation products.

JenKem Technology provides GMP grade PEG derivatives and bulk orders via custom synthesis, offering the opportunity to match customers’ special quality requirements. JenKem Technology is capable of development and synthesis of a wide range of GMP PEG derivatives starting at 200g up to 40 kg or greater batches, under ISO 9001 and ISO 13485 certified quality management system, following ICH Q7A guidelines. For inquiries on cGMP production of PEG derivatives please contact us at

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