Methoxy PEG NHS with Stable Linker

Linear NHS PEGs with Stable Linker from JenKem Technology are amine PEGylation PEGs.

JenKem Technology’s PEG NHS Esters with stable linkers such as M-SCM, M-SPA, M-SBA, M-SHA, M-SGA, M-SSA, are reactive towards the amine group of lysine(s).

Methoxy PEG Succinimidyl Carboxymethyl Ester (SCM) has the shortest hydrolysis half-life among JenKem’s NHS products, offering the fastest reaction time and selectivity. Methoxy PEG Succinimidyl Hexanoate (SHA) provides the longest hydrolysis half-life among the NHS products offered by JenKem Technology.  Glucose PEG NHA and Galactose PEG NHS are amine reactive towards amines of lysine(s) at pH 7-8 at room temperature in <1hr; the presence of the monosaccharide cap increases the selectivity of the PEGylation reaction. NHS PEGs with Stable Linker with molecular weights, branching, and functional groups not listed in our online catalog may be available by custom synthesis. Please inquire at about pricing and availability of custom activated PEGs for amine PEGylation. JenKem Technology provides GMP grade PEG derivatives and bulk orders via custom synthesis, offering the opportunity to match customers’ special quality requirements. JenKem Technology is capable of development and synthesis of a wide range of GMP PEG derivatives starting at 200g up to 40 kg or greater batches, under ISO 9001 and ISO 13485 certified quality management system, following ICH Q7A guidelines. For inquiries on cGMP production of PEG derivatives please contact us at

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