Linear NHS PEGs with Stable Linker from JenKem Technology are amine PEGylation PEGs. JenKem Technology’s PEG NHS Esters with stable linkers such as M-SCM, M-SPA, M-SBA, M-SHA, M-SGA, M-SSA; are reactive towards the amine group of lysine(s) or the N-terminal amines. Methoxy PEG Succinimidyl Carboxymethyl Ester (SCM) has the shortest hydrolysis half-life of JenKem’s NHS products, offering the fastest reaction time and selectivity. Methoxy PEG Succinimidyl Hexanoate (SHA) provides the longest hydrolysis half-life among the NHS products offered by JenKem. Glucose PEG NHA and Galactose PEG NHS are amine reactive towards amines of lysine(s) or N-terminal amine at pH 7-8 at room temperature in <1hr; the presence of the monosaccharide cap increases the selectivity of the PEGylation reaction.
NHS PEGs with Stable Linker with molecular weights, branching, and functional groups not listed in our online catalog may be available by custom synthesis. Please inquire at firstname.lastname@example.org about pricing and availability of custom activated PEGs for amine PEGylation. Bulk PEGs and GMP PEGs are also available upon request. Please contact us for special bulk pricing.