Alkyne PEG Maleimide


PEG products with additional MW may be made to order, please contact us for details


Alkyne PEG Maleimide (Propargyl Maleimide PEG, or Acetylene Maleimide PEG) is a high quality heterobifunctional PEG reagent from JenKem Technology with a standard quality specification of ≥95% Substitution.

The alkyne group of Alkyne PEG Maleimide is reactive towards azides, while the maleimide group is selective for thiol groups on cystein side chains. Heterobifunctional Click Chemistry PEGs from JenKem Technology are generally employed as crosslinking agents or as spacers between two different chemical entities. The PEG moiety in the heterobifunctional PEG derivatives provides water solubility, biocompatibility, and flexibility. The applications of heterofunctional PEGs are especially in the field of antibody drug conjugates (ADC’s).

JenKem Technology offers Alkyne PEG Maleimide with MW 3,500 Da (ALKYNE-PEG3500-MAL), in 1g and 5g packing sizes. Different MW of Alkyne PEG Maleimide products may be available by custom synthesis, please email us at for details on custom PEGs. JenKem Technology provides repackaging services for an additional fee, please contact us if you require a different package size than our catalog selection.

Bulk PEGs and GMP grade PEGs are made-to-order. Please contact us for bulk pricing.


1. Zhou, Z., et al., Herceptin conjugated PLGA-PHis-PEG pH sensitive nanoparticles for targeted and controlled drug delivery, International Journal of Pharmaceutics, 2015, 487:1–2, P. 81-90.

Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.

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