OPSS PEG Succinimidyl Carboxymethyl Ester

Description

High quality OPSS PEG Succinimidyl Carboxymethyl Ester with a standard quality specification of >90% Substitution.

Heterobifunctional OPSS PEG Succinimidyl Carboxymethyl Ester products from JenKem Technology are generally employed as crosslinking agents or as spacers between two different chemical entities. The PEG moiety in the heterofunctional PEG derivatives provides water solubility, biocompatibility, and flexibility. The thiol reactive OPSS group offers the ability to form a disulfide bond, while the SCM group reacts with the amine group of lysine(s). Applications are especially geared towards the development of antibody drug conjugates (ADC’s).

Heterobifunctional PEGylation reagents with molecular weights, branching, and functional groups not listed in our online catalog may be available by custom synthesis. Please inquire at tech@jenkemusa.com about pricing and availability of custom PEGs.

Bulk PEGs and GMP grade PEGs are made-to-order. Please contact us for bulk pricing.

Click here to download the MSDS

References:

1. Laskar, P, et al., Octadecyl chain-bearing PEGylated poly (propyleneimine)-based dendrimersomes: physicochemical studies, redox-responsiveness, DNA condensation, cytotoxicity and gene delivery to cancer cells. Biomaterials Science. 2021, 9(4):1431-48.
2. Tobi, A, et al., Silver nanocarriers targeted with a CendR peptide potentiate the cytotoxic activity of an anticancer drug. Advanced Therapeutics. 2021, 4(1):2000097.
3. Pleiko, K, et al., In vivo phage display: identification of organ-specific peptides using deep sequencing and differential profiling across tissues. Nucleic acids research. 2021, 49(7):e38.
4. Wen, M., et al., Performance of TMC-g-PEG-VAPG/miRNA-145 complexes in electrospun membranes for target-regulating vascular SMCs, Colloids and Surfaces B: Biointerfaces, 2019, 182.
5. Ye, J., et al., Cellular uptake mechanism and comparative in vitro cytotoxicity studies of monomeric LMWP-siRNA conjugate, Journal of Industrial and Engineering Chemistry, 2018.
6. Lee, K., et al., Enhanced accumulation of theranostic nanoparticles in brain tumor by external magnetic field mediated in situ clustering of magnetic nanoparticles, Journal of Industrial and Engineering Chemistry, 2017.
7. Feng, Y., et al., Evaluation of Electrospun PCL-PIBMD Meshes Modified with Plasmid Complexes in Vitro and in Vivo. Polymers, 2016, 8(3), p.58.
8. Braun, G.B., et al., Urokinase-controlled tumor penetrating peptide. Journal of Controlled Release, 2016, 232:188-95.
9. Shin M.C., et al., Preparation and Characterization of Gelonin-Melittin Fusion Biotoxin for Synergistically Enhanced Anti-Tumor Activity. Pharmaceutical research, 2016, 1-1.
10. Zhou, F., et al., Targeted delivery of microRNA-126 to vascular endothelial cells via REDV peptide modified PEG-trimethyl chitosan. Biomaterials science, 2016, 4(5):849-56.
11. Sugahara, K.N., et al., Tumor-Penetrating iRGD Peptide Inhibits Metastasis, Mol. Cancer Ther., 2015, 14, 120.
12. Wang, H., et al., Targeting REDV peptide functionalized polycationic gene carrier for enhancing the transfection and migration capability of human endothelial cells, J. Mater. Chem. B, 2015, 3, 3379-3391.
13. Braun, G.B., Etchable and Bright Silver Nanoparticle Probes for Cell Internalization Assays, Nature Materials, 2014, 13, p: 904–911.
14. Pang, H.B., et al., An endocytosis pathway initiated through ​neuropilin-1 and regulated by nutrient availability, Nature Communications, 2014, 5:4904.
15. Shin, M.C., et al., Combination of antibody targeting and PTD-mediated intracellular toxin delivery for colorectal cancer therapy, Journal of Controlled Release, 194(28), 2014, p: 197-210.
16. Minai, L., et al., High levels of reactive oxygen species in gold nanoparticle-targeted cancer cells following femtosecond pulse irradiation, Scientific Reports, 2013, 3 : 2146.
17. Yeheskely-Hayon, D., et al., Optically Induced Cell Fusion Using Bispecific Nanoparticles, Small, 2013.
18. Agemy, L., et al., Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma PNAS, 2011, 108(42), 17450-17455.
19. Whaley Bishnoi, S., et al., SERS Biodetection Using Gold–Silica Nanoshells and Nitrocellulose Membranes, Analytical Chemistry, 2011, 83(11), p: 4053–4060.

Note: Starting July 2016, OPSS PEG Succinimidyl Carboxymethyl Ester is the new name of the product OPSS PEG NHS Ester (MW 2000 (OPSS-PEG2000-NHS), MW 3500 (OPSS-PEG3500-NHS), MW 5000 (OPSS-PEG5000-NHS) and MW 7500 (OPSS-PEG7500-NHS)).

Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7 guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.