High purity monodisperse (discrete) PEGs (purity> 98% with < 1% single impurity).
Please contact us at sales@jenkemusa.com for a quotation.
High Purity Monodisperse (Discrete) PEG Products
Description
JenKem Technology provides high purity monodisperse discrete PEG raw materials and monodisperse discrete PEG derivatives with an extensive variety of functional groups, from grams to kilogram batch size, in both non-GMP and GMP grade.
The chain lengths for our monodisperse (discrete) PEGs are up to 108 repeating unites (-CH2-CH2-OH-) with molecular weight of about 5000Da, up to 15Kg per batch, with potential to increase the batch size.
The majority of our monodisperse (discrete) PEG products have purity >98% with <1% highest single impurity. The following are some examples of in-stock non-GMP grade monodisperse (discrete) PEG products with even higher purity (>99%):
| Item Number | Item Description |
|---|---|
| HO-PEG7-OH | Heptaethylene Glycol, MW 326.4 |
| HO-PEG8-OH | Octaethylene Glycol, MW 370.4 |
| HO-PEG9-OH | Enneethylene Glycol, MW 414.5 |
| HO-PEG10-OH | Decaethylene Glycol, MW 458.6 |
| HO-PEG11-OH | Undecaethylene Glycol, MW 502.6 |
| HO-PEG12-OH | Dodecaethylene glycol, MW 546.7 |
The following are examples of our monodisperse (discrete) PEG products with purity >98% that have been scaled-up to kilograms batch size:
| Item Number | Item Description |
|---|---|
| HO-PEG9-OH | Enneethylene Glycol, MW 414.5 |
| HO-PEG10-OH | Decaethylene Glycol, MW 458.6 |
| HO-PEG11-OH | Undecaethylene Glycol, MW 502.6 |
| HO-PEG12-OH | Dodecaethylene glycol, MW 546.7 |
| HO-PEG36-OH | Hexatriacontaethylene Glycol, MW 1603.9 |
| M-PEG7-OH | Methoxy PEG7 Hydroxyl, MW 340.4 |
| M-PEG11-OH | Methoxy PEG11 Hydroxyl, MW 516.6 |
| M-PEG11-PA | Methoxy PEG11 Propionic Acid, MW 588.7 |
| Bn-PEG3-OH | Triethylene glycol monobenzyl ether, MW 240.3 |
| Bn-PEG4-OH | Tetraethylene glycol monobenzyl ether, MW 284.4 Da |
| Bn-PEG6-OH | Benzyl PEG6 Hydroxyl, MW 372.5 Da |
| Bn-PEG7-OH | Benzyl PEG7 Hydroxyl, MW 416.5Da |
JenKem Technology provides large scale manufacture of high purity activated heterobifunctional monodisperse PEGs for Antibody-Drug Conjugates (ADCs).
PEG Linkers for ADCs
| Product Name | Molecular Weight |
|---|---|
| NH2-PEG2-PA | 177.2 |
| NH2-PEG3-PA | 221.3 |
| NH2-PEG4-PA | 265.3 |
| NH2-PEG6-PA | 353.4 |
| NH2-PEG7-PA | 397.5 |
| NH2-PEG8-PA | 441.5 |
| NH2-PEG9-PA | 485.6 |
| NH2-PEG10-PA | 529.6 |
| NH2-PEG11-PA | 573.7 |
| NH2-PEG12-PA | 617.7 |
| NH2-PEG24-PA | 1146.4 |
| NH2-PEG8-CM | 427.5 |
| NH2-PEG12-CM | 603.7 |
| NH2-PEG24-CM | 1132.3 |
| DBCO-PEG2-PA | 464.5 |
| DBCO-PEG3-PA | 508.6 |
| DBCO-PEG4-PA | 552.6 |
| DBCO-PEG6-PA | 640.7 |
| DBCO-PEG8-PA | 728.8 |
| DBCO-PEG10-PA | 816.9 |
| DBCO-PEG12-PA | 905.0 |
| DBCO-PEG24-PA | 1433.7 |
| DBCO-PEG8-CM | 714.8 |
| DBCO-PEG12-CM | 891.0 |
| DBCO-PEG24-CM | 1419.7 |
| DBCO-PEG8-NH2 | 655.8 |
| DBCO-PEG12-NH2 | 832.0 |
| DBCO-PEG24-NH2 | 1360.6 |
| MAL-PEG2-PA | 328.3 |
| MAL-PEG3-PA | 372.4 |
| MAL-PEG4-PA | 416.4 |
| MAL-PEG6-PA | 504.5 |
| MAL-PEG8-PA | 592.6 |
| MAL-PEG12-PA | 768.9 |
| MAL-PEG24-PA | 1297.5 |
| MAL-PEG2-SPA | 425.4 |
| MAL-PEG4-SPA | 513.5 |
| MAL-PEG6-SPA | 601.6 |
| MAL-PEG8-SPA | 689.7 |
| MAL-PEG12-SPA | 865.9 |
| MAL-PEG24-SPA | 1394.6 |
| MAL-PEG8-CM | 578.6 |
| MAL-PEG12-CM | 754.8 |
| MAL-PEG24-CM | 1283.5 |
| AZIDE-PEG4-NH2 | 218.3 |
| AZIDE-PEG12-NH2 | 570.7 |
| AZIDE-PEG24-NH2 | 1099.3 |
| AZIDE-PEG4-PA | 291.3 |
| AZIDE-PEG12-PA | 643.7 |
| AZIDE-PEG24-PA | 1172.4 |
| AZIDE-PEG12-CM | 629.7 |
| AZIDE-PEG24-CM | 1158.3 |
| ALKYNE-PEG8-SPA | 577.6 |
| ALKYNE-PEG12-SPA | 753.8 |
| HO-PEG4-ALKYNE | 232.3 |
| DBCO-PEG4-VC-PAB | 914.1 |
| DBCO-PEG6-VC-PAB | 1002.2 |
| DBCO-PEG8-VC-PAB | 1090.3 |
| DBCO-PEG12-VC-PAB | 1266.5 |
| DBCO-PEG24-VC-PAB | 1795.1 |
| DBCO-PEG4-VA-PAB | 828.0 |
| DBCO-PEG6-VA-PAB | 916.1 |
| DBCO-PEG8-VA-PAB | 1004.2 |
| DBCO-PEG12-VA-PAB | 1180.4 |
| DBCO-PEG24-VA-PAB | 1709.0 |
| MAL-PEG4-VC-PAB | 777.9 |
| MAL-PEG6-VC-PAB | 866.0 |
| MAL-PEG8-VC-PAB | 954.1 |
| MAL-PEG12-VC-PAB | 1130.3 |
| MAL-PEG24-VC-PAB | 1658.9 |
| MAL-PEG4-VA-PAB | 691.8 |
| MAL-PEG6-VA-PAB | 779.9 |
| MAL-PEG8-VA-PAB | 868.0 |
| MAL-PEG12-VA-PAB | 1044.2 |
| MAL-PEG24-VA-PAB | 1572.8 |
The following are several high quality monodisperse PROTAC PEG linkers and E3 Ligase Ligand – PEG Linker Conjugates we offer for PROTAC-related applications:
PROTAC PEG Linkers
Amino-PEG2-Propionic Acid
Amino-PEG3-Propionic Acid
Amino-PEG4-Propionic Acid
Amino-PEG2-Acetic Acid
Amino-PEG3-Acetic Acid
Amino-PEG4-Acetic Acid
Amino-PEG4-Alcohol
Azido-PEG3-Alcohol
Azido-PEG3-Acetic Acid
Azido-PEG4-Propionic Acid
Propargyl-PEG6-Propionic Acid
Propargyl-PEG5-Amine
Bis-PEG6-Acid
E3 Ligase Ligand – PEG Linker Conjugates
(S,R,S)-AHPC-PEG2-acid
(S,R,S)-AHPC-PEG4-acid
(S,R,S)-AHPC-PEG6-acid
(S,R,S)-AHPC-PEG2-NH2 hydrochloride
(S,R,S)-AHPC-PEG4-NH2 hydrochloride
(S,R,S)-AHPC-PEG4-azide
(S,R,S)-AHPC-PEG6-alkyne
Thalidomide-O-PEG4-acid
Thalidomide-O-PEG4-NHS ester
Thalidomide-O-PEG4-t-butyl ester
Thalidomide-O-PEG4-amine
Thalidomide-O-PEG4-azide
Thalidomide-O-amido-PEG4-azide
Thalidomide-O-PEG4-propargyl
Thalidomide-O-amido-PEG4-propargyl
Pomalidomide-PEG3-acid
Pomalidomide-PEG4-Ph-NH2
Pomalidomide-PEG4-azide
Please contact us at sales@jenkemusa.com for more information about our linkers for PROTAC applications.
References:
- Zhou X, et al., PROTAC: A promising technology for cancer treatment. Eur J Med Chem. 2020; 203:112539.
- Troup RI, et al., Current strategies for the design of PROTAC linkers: a critical review. Explor Target Antitumor Ther. 2020; 1:273-312.
Please contact us at sales@jenkemusa.com to ask for a quotation.
JenKem Technology specializes in the development and manufacture of high-quality polyethylene glycol (PEG) derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified and adheres to ICH Q7 guidelines for GMP manufacture. The production of JenKem® PEGs is back integrated to in-house polymerization from ethylene oxide to ensure batch to batch consistency. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.
