Acetic Acid PEG12 Acetic Acid

$468.00$1,560.00

PEG products with different MW may be made to order, please contact us for details

Description

Monodisperse Acetic Acid PEG12 Acetic Acid reagent with superior quality specification of ≥ 95% Purity.

Monodisperse Acetic Acid PEG12 Acetic Acid from JenKem Technology (a.k.a. discrete Carboxyl PEG12 Carboxyl, diCarboxy PEG, diAcetic Acid PEG, diCM PEG, or diAA PEG) is a single molecule homobifunctional PEG employed for amine PEGylation.  Monodisperse homobifunctional PEG derivatives from JenKem Technology are high quality crosslinkers for PEGylation of proteins and peptides, nanoparticle and surface modifications. Conjugation with homobifunctional PEGs provides an increased drug load compared to pegylation using linear PEGs. JenKem Technology’s monodisperse Carboxyl PEG Carboxyl products are produced via very reproducible chemical reactions and lack the polydispersity of traditional PEG polymers. JenKem’s monodisperse Carboxyl PEG Carboxyl retain the polyethylene glycol’s good solubility in water, while offering to PEGylated drugs the same PEG benefits of reduced aggregation and immunogenicity, and increased hydrodynamic volume.

JenKem Technology offers monodisperse Acetic Acid PEG8 Acetic Acid with MW 486.5 Da (CM-PEG8-CM) and Acetic Acid PEG12 Acetic Acid with  MW 662.7 Da (CM-PEG12-CM), in 1g and 5g packing sizes. diCarboxyl PEGs with different numbers of -CH2-CH2-O- units such as Acetic Acid PEG4 Acetic Acid (CM-PEG4-CM) may be available by custom synthesis, please email us at tech@jenkemusa.com for details on custom PEGs. JenKem Technology provides repackaging services for an additional fee, please contact us if you require a different package size than our catalog selection. Bulk PEGs and GMP PEGs are also available upon request. Please contact us for special bulk pricing.

References:

1. Xu, P., et al., Hydrogen-bonded and reduction-responsive micelles loading atorvastatin for therapy of breast cancer metastasis. Biomaterials, 2014. 35(26): p. 7574-7587.

2. Gajbhiye, V., et al., Drug-loaded nanoparticles induce gene expression in human pluripotent stem cell derivatives. Nanoscale, 2014. 6(1): p. 521-31.

3. Gao, X., et al., Prostate stem cell antigen-targeted nanoparticles with dual functional properties: in vivo imaging and cancer chemotherapy. Int J Nanomedicine, 2012. 7: p. 4037-51.

4. Hutanu D, et al., (2014) Recent Applications of Polyethylene Glycols (PEGs) and PEG Derivatives. Mod Chem appl 2:132. doi: 10.4172/2329-6798.1000132. Read about select applications of JenKem® PEGs in the medical device, drug development, and diagnostics areas, including drug delivery, wound healing, cell culture models, and tissue regeneration.

Note: Starting July 2016, Acetic Acid PEG Acetic Acid is the new name of the product Carboxyl PEG Carboxyl (MW 486.5 (CM-PEG8-CM), MW 662.7 (CM-PEG12-CM)). JenKem Technology has revised the name of the product to better reflect the chemical structure, as many other PEG derivatives with a COOH group are offered in the 2016 JenKem USA catalog.

Founded in 2001 by recognized experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom polymer synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to on-site manufacturing from ethylene oxide, enabling facile traceability for GMP regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.