Methoxy PEG Acetic Acid

$100.00$800.00

PEG products with additional MW may be made to order, please contact us for details

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Description

Methoxy PEG Acetic Acid with superior quality specification of ≥95% Substitution.

Methoxy PEG Acetic Acid from JenKem Technology is an Amine PEGylation reagent reactive towards the amino group of lysine(s) at pH 7-8. Methoxy PEG Acetic Acid is more stable than M-PEG-SCM. JenKem Technology offers Methoxy PEG Acetic Acid with MW 5000 (M-CM-5000), MW 10000 (M-CM-10K) and MW 20000 (M-CM-20K), in 1g and 10g packing sizes.

Different MW of Methoxy PEG Acetic Acid products may be available by custom synthesis, please email us at tech@jenkemusa.com for details on custom PEGs. JenKem Technology provides repackaging services for an additional fee, please contact us if you require a different package size than our catalog selection. Bulk PEGs and GMP PEGs are also available upon request. Please contact us for special bulk pricing.

Click here to download the MSDS

Note: Starting July 2016, Methoxy PEG Acetic Acid is the new name of the product Methoxy PEG Carboxyl (MW 5000 (M-COOH-5000), MW 10000 (M-COOH-10K) and MW 20000 (M-COOH-20K)). JenKem Technology has revised the name of the product to better reflect the chemical structure, as many other PEG derivatives with a COOH group are offered in the 2016 JenKem USA catalog.  

References:

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9. Li, Y., et al., A graphene quantum dot (GQD) nanosystem with redox-triggered cleavable PEG shell facilitating selective activation of the photosensitiser for photodynamic therapy, RSC Adv., 2016, 6, 6516-6522.

10. Jones, S.K, et al., Folate Receptor Targeted Delivery of siRNA and Paclitaxel to Ovarian Cancer Cells via Folate Conjugated Triblock Copolymer to Overcome TLR4 Driven Chemotherapy Resistance, Biomacromolecules, 2016, 17 (1), 76-87.

11. Chaudhary, R., et al., Engineered atherosclerosis-specific zinc ferrite nanocomplex-based MRI contrast agents. Journal of Nanobiotechnology, 2016, 14(1):1-7.

12. Abolmaali, S.S., et al., Chemically crosslinked nanogels of PEGylated poly ethyleneimine (l-histidine substituted) synthesized via metal ion coordinated self-assembly for delivery of methotrexate: Cytocompatibility, cellular delivery and antitumor activity in resistant cells. Materials Science and Engineering, 2016, C, 62, pp.897-907.

13. Brinkman, A.M., et al., Aminoflavone-loaded EGFR-targeted unimolecular micelle nanoparticles exhibit anti-cancer effects in triple negative breast cancer. Biomaterials. 2016, 101:20-31.

14. Li, C. et al., A self-assembled nanoparticle platform based on poly(ethylene glycol)–diosgenin conjugates for co-delivery of anticancer drugs, RSC Adv., 2015, 5, 74828-74834.

15. Najafi, H., et al., Serum resistant and enhanced transfection of plasmid DNA by PEG-stabilized polyplex nanoparticles of L-histidine substituted polyethyleneimine, Macromolecular Research, 2015, Volume 23, Issue 7, p. 618-627.

16. Saraswathy, M., et al., Multifunctional drug nanocarriers formed by cRGD-conjugated βCD-PAMAM-PEG for targeted cancer therapy, Colloids and Surfaces B: Biointerfaces, 2015, Volume 126, p. 590-597.

17. Chen, G., et al., Multi-functional self-fluorescent unimolecular micelles for tumor-targeted drug delivery and bioimaging, Biomaterials 2015, Volume 47, Pages 41-50.

18. Xiong, D, et al., GX1-mediated anionic liposomes carrying adenoviral vectors for enhanced inhibition of gastric cancer vascular endothelial cells, International Journal of Pharmaceutics, 2015, Volume 496, Issue 2, p. 699-708.

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20. Xu, P., et al., Hydrogen-bonded and reduction-responsive micelles loading atorvastatin for therapy of breast cancer metastasis. Biomaterials, 2014. 35(26): p. 7574-7587.

21. Gajbhiye, V., et al., Drug-loaded nanoparticles induce gene expression in human pluripotent stem cell derivatives. Nanoscale, 2014. 6(1): p. 521-31.

22. Abolmaali, S.S., et al., Sequential optimization of methotrexate encapsulation in micellar nano-networks of polyethyleneimine ionomer containing redox-sensitive cross-links, International Journal of Nanomedicine. 2014, 9:2833-2848.

23. Guo, J., et al., Image-guided and tumor-targeted drug delivery with radiolabeled unimolecular micelles, Biomaterials 2013, 34(33), p: 8323–8332.

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25. Jiang, X., et al., Self-aggregated pegylated poly (trimethylene carbonate) nanoparticles decorated with c(RGDyK) peptide for targeted paclitaxel delivery to integrin-rich tumors, Biomaterials 2011, 32(35), p:9457–9469.

Founded in 2001 by recognized experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to on-site manufacturing from ethylene oxide, enabling facile traceability for GMP regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.

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