Made to order. Please contact us for a quotation.
Methoxy PEG Epoxide
Description
High quality Methoxy PEG Epoxide (M-PEG-EPOX). JenKem Technology provides large scale GMP manufacture of Methoxy PEG Epoxide widely used for Lipid Nanoparticles and RNA delivery.
LNPs drug delivery systems are commonly employed for nucleic acid drugs. LNPs are generally believed to
combine with the cell membrane through noncovalent affinity and absorbed by endocytosis. After being absorbed by the cell, the mRNA delivered by LNPs are released to the cytoplasm and express the target protein, escaping from the endocytosis. This technology has been adopted by pharmaceutical companies in the recent years for COVID-19 vaccine manufacture [1].
Different MW of Methoxy PEG Epoxide (500Da-40KDa) are available by custom synthesis, please email us at tech@jenkemusa.com for details on custom PEGs. JenKem Technology provides repackaging services for an additional fee, please contact us if you require a different package size than our catalog selection.
Bulk PEGs and GMP grade PEGs are made-to-order. Please contact us for bulk pricing.
References:
1. Schoenmaker, Linde, et al., mRNA-lipid nanoparticle COVID-19 vaccines: structure and stability, International Journal of Pharmaceutics 601 (2021)
Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7 guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization directly from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.
