8arm PEG (hexaglycerol), 7arm-Hydroxyl, 1arm-Acetic Acid

Description

8arm PEG (hexaglycerol), 7arm-Hydroxyl, 1arm-Acetic Acid from JenKem Technology is a high quality octa arm heterobifunctional mono activated PEG linker. JenKem Technology’s multi-arm heterofunctional reactive PEG Derivatives are designed as linkers for Antibody-Drug Conjugates (ADCs), as they facilitate the coupling of high ratios of drug molecule per antibody. ADCs conjugated via multiarm PEGs deliver a higher concentration of drugs to targets for each antibody-antigen interaction, and exhibit an improved solubility and PK/PD profile.

Multi-arm Heterofunctional PEG reagents with molecular weights, branching, and functional groups not listed in our online catalog may be available by custom synthesis. Please inquire at tech@jenkemusa.com about pricing and availability.

Bulk PEGs and GMP PEGs are made-to-order. Please contact us for bulk pricing.

JenKem Technology also provides 8ARM(TP)-PEG hydroxyl raw materials and PEG derivatives with tripentaerythritol core. 8ARM(TP)-PEGs with tripentaerythritol core have a higher purity as evidenced by MALDI compared with the generic 8ARM-PEGs with a hexaglycerin core.

Click here to download the MSDS

References:

1. Hutanu D, Frishberg MD, Guo L, Darie CC (2014) Recent Applications of Polyethylene Glycols (PEGs) and PEG Derivatives. Mod Chem appl 2:132. doi: 10.4172/2329-6798.1000132. Read about select applications of JenKem® PEGs in the medical device, drug development, and diagnostics areas, including drug delivery, wound healing, cell culture models, and tissue regeneration.

Note: Starting July 2016, 8arm PEG (hexaglycerol), 7arm-Hydroxyl, 1arm-Acetic Acid is the new name of the product 8arm PEG (hexaglycerol), 7arm-Hydroxyl, 1arm-Carboxyl (MW 10000 ((HO)7-8ARMPEG10K-COOH) and MW 20000 ((HO)7-8ARMPEG20K-COOH)). JenKem Technology has revised the name of the product to better reflect the chemical structure, as many other PEG derivatives with a COOH group are offered in the 2016 JenKem USA catalog.

Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.