Cell Penetrating Peptide-PEGs For Oligonucleotide Drug Delivery Launched at TIDES

“Novel Cell-Penetrating Drug Delivery System for siRNA” poster was presented by JenKem Technology and Tianjin Medical University at the 2018 TIDES meeting.PEGs for siRNA Delivery Poster _ JenKemsiRNA Drug Delivery PEGs_JenKem Technology

Experience has shown that siRNA drugs, while potentially very useful, are easily degraded by nucleases in vivo, and their relatively high molecular weight, negative charge and hydrophilicity inhibit their ability to permeate through cell membranes

To circumvent these deficiencies, a novel drug delivery system consisting of a cell penetrating peptide linked to activated PEGs (polyethylene glycol polymers) has been developed for siRNA delivery.

The addition of the PEG improves the drug’s bioavailability by preventing the self-assembly and formation of intra-molecular hairpin structures between the cell penetrating peptide and siRNA .CPP-PEG

In vitro findings confirmed that our novel LMWP-PEG drug delivery system yields successful cellular uptake of siRNA and high gene-silencing efficacy.

LMWP-PEGs can be employed to deliver oligonucleotides for gene therapy, and other drug molecules that cannot penetrate the cell membrane on their own. For information please contact us. 

 

References:

1. Zhao, X., et al., Novel Cell-Penetrating Drug Delivery System for siRNA, Poster presentation at 2018 TIDES.

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