Galactose PEG Succinimidyl Carboxymethyl Ester

Description

Galactose PEG Succinimidyl Carboxymethyl Ester with superior quality specification of ≥90% Substitution.

Galactose PEG Succinimidyl Carboxymethyl Ester is a JenKem Technology high quality amine reactive PEG product with a succinimidyl carboxymethyl ester reactive group and a targeting galactose group. Galactose PEG SCM reacts with amino group of lysine(s) at room temperature in under 1hr, at pH 7-8. The presence of the galactose monosaccharide increases significantly the selectivity of the PEGylation reaction.

JenKem Technology offers Galactose PEG Succinimidyl Carboxymethyl Ester with MW 35000 (GALA-SCM-35K), in 1g and 10g packing sizes. Different MW of Galactose PEG Succinimidyl Carboxymethyl Ester products may be available by custom synthesis, please email us at tech@jenkemusa.com for details on custom PEGs. JenKem Technology provides repackaging services for an additional fee, please contact us if you require a different package size than our catalog selection.

Bulk PEGs and GMP grade PEGs are made-to-order. Please contact us for bulk pricing.

Click here to download the MSDS

References:

1. Luan, J., et al., GSDMD membrane pore is critical for IL-1β release and antagonizing IL-1β by hepatocyte-specific nanobiologics is a promising therapeutics for murine alcoholic steatohepatitis, Biomaterials, 2020, V. 227.
2. He, H., et al., Development of mannose functionalized dendrimeric nanoparticles for targeted delivery to macrophages: use of this platform to modulate atherosclerosis, Translational Research, 2018, 193, P. 13-30.
3. He, H., et al., Bolstering cholesteryl ester hydrolysis in liver: A hepatocyte-targeting gene delivery strategy for potential alleviation of atherosclerosis, Biomaterials, 2017, 130:1-3.
4. Weaver, E.A., et al., Effects of Shielding Adenoviral Vectors with Polyethylene Glycol on Vector-Specific and Vaccine-Mediated Immune Responses, Human Gene Therapy, 2008, 19:1369–1382.

Note: Starting July 2016, Galactose PEG Succinimidyl Carboxymethyl Ester is the new name of the product Galactose PEG NHS Ester (MW 35000 (GALA-NHS-35K)).

Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization directly from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.