Multi-arm Heterobifunctional PEGs for ADCs

JenKemPEGProductionJenKem Technology provides high quality activated multi-arm heterobifunctional polyethylene glycol derivatives (PEGs) for ADCs with high purity and low polydispersity.

JenKem Technology’s patented multi-arm heterofunctional PEG Derivatives are designed as linkers for Antibody-Drug Conjugates or ADCs, as they facilitate the coupling of high ratios of drug molecules  per antibody [1]. ADCs conjugated via multiarm PEGs deliver a higher concentration of drug to target for each antibody-antigen interaction, and exhibit improved solubility and PK/PD profile.

Multi-arm heterobifunctional PEG Derivatives are designed for connecting two different drugs at the same time, offering dual synergistic function and increased drug loading.

JenKem Technology now provides various multi-arm heterobifunctional PEG derivatives. Multi-arm Heterofunctional PEG products with molecular weights and functional groups not listed in our online catalog may be available by custom synthesis. Please inquire at tech@jenkemusa.com about pricing and availability. For global distribution, please visit link. To order directly from JenKem Technology:

ORDER ONLINE
4arm Heterobifunctional PEGs for ADCs
PEG PRODUCT FIRST FUNCTIONAL GROUP SECOND FUNCTIONAL GROUP SUBSTITUTION
(HO)3-4ARMPEG-COOH Hydroxyl (3) Carboxyl (1) ≥ 95%
(HO)3-4ARMPEG-NH2 Hydroxyl (3) Amine (1) ≥ 95%
(HO)2-4ARMPEG-(COOH)2 Hydroxyl (2) Carboxyl (2) ≥ 95%
(HO)2-4ARMPEG-(NH2)2 Hydroxyl (2) Amine (2) ≥ 95%
HO-4ARMPEG-(COOH)3 Hydroxyl (1) Carboxyl (3) ≥ 95%
(CH3O)3-4ARMPEG-NHS Methoxy (3) SCM (1) ≥ 90%
(HO)3-4ARMPEG10K-TBOC Hydroxyl (3) t-BOC (1) ≥ 95%
8arm Heterobifunctional PEGs for ADCs
PEG PRODUCT FIRST FUNCTIONAL GROUP SECOND FUNCTIONAL GROUP SUBSTITUTION
(HO)7-8ARMPEG-COOH Hydroxyl (7) Carboxyl (1) ≥ 95%
(HO)7-8ARM(TP)PEG-COOH Hydroxyl (7) Carboxyl (1) ≥ 95%
Linear 2arm Heterobifunctional PEGs for ADCs
Linear Heterobifunctional PEGs

References:

1. Dai, L., et al., Novel Multiarm Polyethylene glycol-Dihydroartemisinin Conjugates Enhancing Therapeutic Efficacy in Non-Small-Cell Lung Cancer, Scientific Reports, 2014, 4, 5871.

Founded in 2001 by recognized experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to on-site manufacturing from ethylene oxide, enabling facile traceability for GMP regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.