JenKemPEGProductionJenKem Technology provides high quality activated multi-arm heterobifunctional polyethylene glycol derivatives (PEGs) for ADCs with high purity and low polydispersity.

JenKem Technology’s patented multi-arm heterofunctional PEG Derivatives are designed as linkers for Antibody-Drug Conjugates or ADCs, as they facilitate the coupling of high ratios of drug molecules per antibody. ADCs conjugated via multiarm PEGs deliver a higher concentration of drug to target for each antibody-antigen interaction, and exhibit improved solubility and PK/PD profile.

Multi-arm heterobifunctional PEG Derivatives are designed for connecting two different drugs at the same time, offering dual synergistic function and increased drug loading. JenKem Technology now provides various multi-arm heterobifunctional PEG derivatives. 8ARM(TP)-PEGs with tripentaerythritol core have a higher purity as evidenced by MALDI compared with the generic 8ARM-PEGs with a hexaglycerin core. 8ARM TP CORE ADVANTAGES

Multi-arm Heterofunctional PEG products with molecular weights and functional groups not listed in our online catalog may be available by custom synthesis. Please inquire at about pricing and availability. For global distribution, please visit link.

To order online directly from JenKem Technology please click on the links below:

4arm Heterobifunctional PEGs for ADCs
Hydroxyl (3) Carboxyl (1) ≥ 95%
Hydroxyl (3) Amine (1) ≥ 95%
Hydroxyl (2) Carboxyl (2) ≥ 95%
Hydroxyl (2) Amine (2) ≥ 95%
Hydroxyl (1) Carboxyl (3) ≥ 95%
Methoxy (3) SCM (1) ≥ 90%
Hydroxyl (3) t-BOC (1) ≥ 95%
8arm Heterobifunctional PEGs for ADCs
Hydroxyl (7) Carboxyl (1) ≥ 95%
Hydroxyl (7) Carboxyl (1) ≥ 95%
Linear 2arm Heterobifunctional PEGs for ADCs

1. Coppock, M.B., et al., A Universal Method for the Functionalization of Dyed Magnetic Microspheres with Peptides, Methods, 2019.

2. Coppock, M.B., et al., A novel discovery, maturation, and assay integration approach for the development of ruggedized multi-valent capture receptors exemplified against the chikungunya virus E2 protein, Sensing and Bio-Sensing Research, 2019, Vol. 22.

3. Liu, K.F., et al., A novel self-assembled pH-sensitive targeted nanoparticle platform based on antibody–4arm-polyethylene glycol–pterostilbene conjugates for co-delivery of anticancer drugs, Journal of Materials Chemistry B., 2018.

4. Dai, L., et al., Novel Multiarm Polyethylene glycol-Dihydroartemisinin Conjugates Enhancing Therapeutic Efficacy in Non-Small-Cell Lung Cancer, Scientific Reports, 2014, 4, 5871.

Founded in 2001 by recognized experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to on-site manufacturing from ethylene oxide, enabling facile traceability for GMP regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.