JenKemPEGProductionJenKem Technology provides high quality activated multi-arm heterobifunctional PEGs with high purity and low polydispersity.

JenKem Technology’s patented multi-arm heterofunctional PEG Derivatives are designed as linkers for Antibody-Drug Conjugates or ADCs, as they facilitate the coupling of high ratios of drug molecules per antibody. ADCs conjugated via multiarm PEGs deliver a higher concentration of drug to target for each antibody-antigen interaction, and exhibit improved solubility and PK/PD profile. Multi-arm heterobifunctional PEG Derivatives are also ideal for connecting two different drugs at the same time, thus offering dual synergistic function and increased drug loading.

JenKem Technology provides various multi-arm heterobifunctional polyethylene glycol derivatives with different branching and functionalities. JenKem Technology reports the total molecular weight of multi-arm PEG raw materials as the sum of the molecular weights of all the arms. The number of ethylene oxide units in the PEG chain may not be equal for all arms. 8ARM(TP)-PEGs with tripentaerythritol core have a higher purity as evidenced by MALDI compared with the generic 8ARM-PEGs with a hexaglycerin core. 8ARM TP CORE ADVANTAGES

Multi-arm Heterofunctional PEG products with molecular weights and functional groups not listed in our online catalog may be available by custom synthesis. Please inquire at tech@jenkemusa.com about pricing and availability of custom PEGs.

JenKem Technology provides GMP grade PEG derivatives and bulk orders via custom synthesis, offering the opportunity to match customers’ special quality requirements. JenKem Technology is capable of development and synthesis of a wide range of GMP PEG derivatives starting at 200g up to 40 kg or greater batches, under ISO 9001 and ISO 13485 certified quality management system, following ICH Q7A guidelines. For inquiries on cGMP production of PEG derivatives please contact us at tech@jenkemusa.com.

For global distribution, please visit link. Please click the buttons below to order directly from JenKem Technology:

4arm Heterobifunctional PEGs
PEG PRODUCT FIRST FUNCTIONAL GROUP SECOND FUNCTIONAL GROUP SUBSTITUTION
Hydroxyl (3) Carboxyl (1) ≥ 95%
Hydroxyl (3) Amine (1) ≥ 95%
Hydroxyl (2) Carboxyl (2) ≥ 95%
Hydroxyl (2) Amine (2) ≥ 95%
Hydroxyl (1) Carboxyl (3) ≥ 95%
Methoxy (3) SCM (1) ≥ 90%
Hydroxyl (3) t-BOC (1) ≥ 95%
8arm Heterobifunctional PEGs
PEG PRODUCT FIRST FUNCTIONAL GROUP SECOND FUNCTIONAL GROUP SUBSTITUTION
Hydroxyl (7) Carboxyl (1) ≥ 95%
Hydroxyl (7) Carboxyl (1) ≥ 95%
Linear 2arm Heterobifunctional PEGs

 

 

References:

  1. Coppock, M.B., et al., A Universal Method for the Functionalization of Dyed Magnetic Microspheres with Peptides, Methods, 2019.
  2. Coppock, M.B., et al., A novel discovery, maturation, and assay integration approach for the development of ruggedized multi-valent capture receptors exemplified against the chikungunya virus E2 protein, Sensing and Bio-Sensing Research, 2019, 22.
  3. Liu, K.F., et al., A novel self-assembled pH-sensitive targeted nanoparticle platform based on antibody–4arm-polyethylene glycol–pterostilbene conjugates for co-delivery of anticancer drugs, Journal of Materials Chemistry B., 2018.
  4. Dai, L., et al., Novel Multiarm Polyethylene glycol-Dihydroartemisinin Conjugates Enhancing Therapeutic Efficacy in Non-Small-Cell Lung Cancer, Scientific Reports, 2014, 4, 5871.

Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.