JenKem PEG RnDJenKem Technology’s monodisperse PEG products are produced via very reproducible chemical reactions and lack the polydispersity of traditional PEG polymers. JenKem Technology’s monodisperse PEG products consist of linear chains of up to 48 –CH2-CH2-O– units, and various terminal functional and reactive groups. Monodisperse JenKem PEGs retain polyethylene glycol’s good solubility in water, offering to PEGylated drugs the same PEG benefits of reduced aggregation and immunogenicity, and increased hydrodynamic volume.

Monodisperse PEG products with molecular weights and functional groups not listed in our online catalog may be available by custom synthesis. JenKem Technology provides GMP grade PEG derivatives and bulk orders via custom synthesis, offering the opportunity to match customers’ special quality requirements. JenKem Technology is capable of development and synthesis of a wide range of GMP PEG derivatives starting at 200g up to 40 kg or greater batches, under ISO 9001 and ISO 13485 certified quality management system, following ICH Q7A guidelines. For inquiries on custom production of PEG derivatives and PEGylation services please contact us at tech@jenkemusa.com.

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MONODISPERSE PEG PRODUCTS MW PURITY
252.2 ≥ 95%
296.2 ≥95%
251.4 ≥95%
295.3 ≥95%
324.4 ≥95%
368.2 ≥95%
277.3 ≥90%
321.4 ≥90%
268.4 ≥90%
312.4 ≥90%
306.3 ≥90%
350.4 ≥90%
370.5 ≥95%
414.5 ≥95%
546.7 ≥95%
368.5 ≥95%
544.8 ≥95%
486.5 ≥95%
662.7 ≥95%
514.6 ≥95%
674.8 ≥95%
369.5 ≥95%
545.8 ≥95%
428.5 ≥95%
604.8 ≥95%
442.5 ≥95%
618.8 ≥95%

References

1. El-Gogary, R.I., et al., Polyethylene Glycol Conjugated Polymeric Nanocapsules for Targeted Delivery of Quercetin to Folate-Expressing Cancer Cells in Vitro and in Vivo. ACS Nano, 2014, 8(2): p. 1384-1401.

2. Zhou, J., et al., In vivo evaluation of medical device-associated inflammation using a macrophage-specific positron emission tomography (PET) imaging probe. Bioorganic & Medicinal Chemistry Letters, 2013, 23(7): p. 2044-2047.

3. Hutanu D, et al.,  Recent Applications of Polyethylene Glycols (PEGs) and PEG Derivatives. Mod Chem appl, 2014, 2:132. Read about select applications of JenKem® PEGs in the medical device, drug development, and diagnostics areas, including drug delivery, wound healing, cell culture models, and tissue regeneration.

Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.