Linear Monofunctional PEGs for PEGylation

JenKem PEGylation ReagentsJenKem Technology provides high quality linear reactive polyethylene glycol (PEG) products for PEGylation, with high purity, low polydispersity, and low to no diol content.

JenKem Technology’s linear monofunctional PEG derivatives have a reactive group at one end of the PEG polymer chain, while the other end is capped with a methoxy group or a sugar group. JenKem Technology provides linear methoxy PEG derivatives for amine PEGylation, thiol PEGylation, N-terminal PEGylation, and C-terminal PEGylation, for various applications [1]. Linear monofunctional PEG derivatives have the general structure: CAP―PEG―X, where X is the functional reactive group and CAP can be either a methoxy group (methoxy PEGs) or a targeting monosaccharide molecule (such as glucose-PEG and galactose-PEG).JenKem PEG Quality

Linear monofunctional PEG products with molecular weights and functional groups not listed in our online catalog may be available by custom synthesis.

Please inquire at tech@jenkemusa.com about pricing and availability. For global distribution, please visit link. To order directly from JenKem Technology:

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Linear NHS mPEGs with Cleavable Linker
PEG PRODUCT SUBSTITUTION REACTIVITY DETAILS
M-PEG-SS ≥ 95% Methoxy PEG Succinimidyl Succinate is a degradable PEG linker reacting with the amino group of lysine(s) on proteins or other biologics, such as the amines on the active ingredients of Adagen®, Pegademase, PEG-adenosine deaminase, PEG aspargase, PEG-L-asparaginase, and related biosimilars, at pH 7-8, while the ester linkage is cleaved under regular ester cleaving reaction conditions.[2,3]
M-PEG-SG ≥ 95% Methoxy PEG Succinimidyl Glutarate is a degradable PEG linker that reacts with the amino group of lysine(s) on proteins or other biologics at pH 7-8, while the ester linkage is cleaved under regular ester cleaving reaction conditions.
Linear Monosaccharide NHS PEGs
PEG PRODUCT SUBSTITUTION REACTIVITY DETAILS
GALA-PEG-NHS ≥ 90% Galactose PEG NHS reacts with amino group of lysine(s) at room temperature in under 1hr, at pH 7-8. The presence of the targeting galactose monosaccharide increases significantly the selectivity of the PEGylation reaction. [5]
GLUC-PEG-NHS ≥ 90% Glucose PEG NHS reacts with amine group of lysine(s) at room temperature in less than 1hr, at pH 7-8. The presence of the targeting sugar group (Glucose) increases significantly the selectivity of the PEGylation reaction. [5, 6]
Linear Methoxy NHS mPEGs with Stable Linker
PEG PRODUCT SUBSTITUTION REACTIVITY DETAILS
M-PEG-SCM ≥ 95% Methoxy PEG Succinimidyl Carboxymethyl Ester reacts with the amine group of lysine(s) at room temperature in less than 1hr at pH 7-8. Shorter hydrolysis half life of M-PEG-SCM ensures maximum selectivity towards most sterically available amine groups. [7-9, 46, 47]
M-PEG-SPA ≥ 95% Methoxy PEG Succinimidyl Propionate (Methoxy PEG Succinimidyl Propanoate) reacts with the amine group of lysine(s, such as amines on the active ingredients of Somavert®, PEG-HGH antagonist, Pegvisomant, PEG growth hormone B2036, pegylated granulocyte colony stimulating factor MAXY-G34 ( PEG-CSF MAXY-G34), or Puricase PEG-uricase, Pegloticase, or Krystexxya®, and related biosimilars. [12]
M-PEG-SBA ≥ 95% Methoxy PEG Succinimidyl Butanoate reacts with the amine group of lysine(s), such as the amines on active ingredients of Mircera®, or Peg-epo biosimilars, at room temperature at pH 7-8. Methoxy PEG Succinimidyl Butanoate has a longer hydrolysis half-life compared with M-PEG-SCM.
M-PEG-SHA ≥ 95% Methoxy PEG Succinimidyl Hexanoate reacts with the amine group of lysine(s) at pH 7-8. Methoxy PEG Succinimidyl Hexanoate has a longer hydrolysis half-life compared with M-PEG-SCM and M-PEG-SBA. [10, 48, 49]
M-PEG-SSA ≥ 95% Methoxy PEG Succinimidyl Succinamide reacts with the amine group of lysine(s) at pH 7-8. Methoxy PEG Succinimidyl Succinamide has a longer hydrolysis half-life compared with M-PEG-SCM.[11]
M-PEG-SGA ≥ 90% Methoxy PEG Succinimidyl Glutaramide reacts with the amine group of lysine(s) at pH 7-8. Methoxy PEG Succinimidyl Glutaramide has a longer hydrolysis half-life compared with M-PEG-SCM. [12]
Linear Carbonate mPEGs
PEG PRODUCT SUBSTITUTION REACTIVITY DETAILS
M-PEG-SC ≥ 95% Methoxy PEG Succinimidyl Carbonate reacts with the amino group of lysine(s) on proteins or other biologics, such as the amiens present on proteins for Peg-intron, PEG-IFN, Interferon alpha 2b, Pegintron®, Redipen, Sylatron and related biosimilars. Methoxy PEG Succinimidyl Carbonate has a longer hydrolysis half-life compared with M-PEG-SCM.[4]
M-PEG-NPC ≥ 90% Methoxy PEG Nitrophenyl Carbonate is reactive towards the the amino group of lysine(s) on proteins or other biologics, with a longer hydrolysis half-life compared with M-PEG-SCM.
Linear Carboxyl mPEGs
PEG PRODUCT SUBSTITUTION REACTIVITY DETAILS
M-PEG-CM ≥ 95% Methoxy PEG Carboxyl (Methoxy PEG Acetic Acid, or M-PEG-COOH) is more stable than M-PEG-SCM.[16, 17, 50-52]
M-PEG-PA ≥ 95% Methoxy PEG Propionic Acid (Methoxy PEG Propanoic Acid) is more stable than M-PEG-SPA.[54]
M-PEG-BA ≥ 95% Methoxy PEG Butanoic Acid (Methoxy PEG Butyric Acid) is more stable than M-PEG-SBA.
M-PEG-HA ≥ 95% Methoxy PEG Hexanoic Acid  is more stable than M-PEG-SHA.
Linear Methoxy PEG Amine
PEG PRODUCT SUBSTITUTION REACTIVITY DETAILS
M-PEG-NH2 ≥ 95% Methoxy PEG Amine. Attaches via stable linkages, such as amide, urethane, urea, secondary amine; the HCl salt form provides stability for the solid form of M-PEG-NH2 [18, 53, 55]
Linear Methoxy PEG Aldehyde
PEG PRODUCT SUBSTITUTION REACTIVITY DETAILS
M-PEG-ALD ≥ 95% Methoxy PEG Aldehyde reacts with N-terminal amines, such as the N-terminal on proteins for Peg-filgastrim Peg-gsf, PEG-rhGCSF, Neulasta®, and related biosimilars, at pH 5-8 in the presence of a reducing reagent. [19-21]. Methoxy Propionaldehyde PEG with MW 20000 (M-ALD-20K) is utilized as a PEG raw material for pegfilgrastim PEGylated biosimilars [22].
Linear Methoxy Maleimide PEGs
PEG PRODUCT SUBSTITUTION REACTIVITY DETAILS
M-PEG-MAL ≥ 95% Methoxy PEG Maleimide from JenKem Technology is a thiol reactive PEG derivative selective for thiol groups on cystein side chains. Methoxy PEG Maleimide undergoes thiol PEGylation reactions with thiol-containing molecules at pH 5.0-6.5.[23-25]
Linear Methoxy Vinylsulfone PEGs
PEG PRODUCT SUBSTITUTION REACTIVITY DETAILS
M-PEG-VS ≥ 90% Methoxy PEG Vinylsulfone are high quality products for sulfhydryl PEGylation. Methoxy Vinylsulfone PEG products are special thiol PEGylation PEGs that react at high pH. [26]
Linear Methoxy Thiol PEGs
PEG PRODUCT SUBSTITUTION REACTIVITY DETAILS
M-PEG-SH ≥ 95% Methoxy PEG Thiol is a high quality activated PEG product for thiol pegylation. Methoxy PEG Thiol PEGylates the thiol groups on cysteine side chains under mild reaction conditions.[27-30]
Biodegradable M-PEG Oligopeptides
PEG PRODUCT SUBSTITUTION REACTIVITY DETAILS
M-PEG-GLU2 ≥95% Methoxy PEG Di-Glutamic Acid. Oligopeptide PEG for micelle formation used for drug encapsulation and drug delivery
M-PEG-GLU3 ≥90% Methoxy PEG Tri-Glutamic Acid. Oligopeptide PEG for micelle formation useful in drug encapsulation and drug delivery
PLL20K-G35-PEG2K ≥90%(Main peak wt%) PLL20K-G35-PEG2K, PEG-Poly(L-lysine), Poly(L-lysine), Graft Ratio 3.5, PLL MW 20000, PEG MW 2000 [31-35]
Click Chemistry PEGs
PEG PRODUCT SUBSTITUTION REACTIVITY DETAILS
M-PEG-ALKYNE ≥90% Methoxy PEG Alkyne. Click chemistry PEG reagent for reaction with azide groups
M-PEG-AZIDE ≥90% Methoxy PEG Azide. The azide group may be reduced to amines by hydrogenolysis. Click PEG reagent for reaction with alkynes, simple reaction conditions, high selectivity, and rapid reaction with high yield. Water can be used as the reaction solvent. [36]
Other Special mPEG Products
PEG PRODUCT SUBSTITUTION REACTIVITY DETAILS
M-PEG-HZ ≥95% Methoxy PEG Hydrazide reacts with aldehydes and ketones to give stable hydrazones in a single step; it can also react with activated carboxylic acids [37]
M-PEG-BIOTIN ≥90% Methoxy PEG Biotin. Avidin reactive PEG. Streptavidin reactive PEG. [38]
M-PEG-SLN ≥90% Methoxy PEG Silane for glass or silica surface modification and deactivation [39, 40]
M-PEG-ACLT ≥90% Methoxy PEG Acrylate reacts with sulfhydryl groups (Michael addition reaction). Used for Vinyl polymerization or co-polymerization [41]
M-PEG-PHOS ≥95% Methoxy PEG Phosphate. PEG reagent for surface modifications; increases water solubility. [42]
M-PEG-TA ≥90% Methoxy PEG Lipoic Acid. (mPEG Thioctic Acid). High affinity for metals, useful for gold nanoparticle surface modification. [43]
M-PEG-DSPE ≥95% Methoxy PEG DSPE mPEG phospholipid for liposome formation. [44, 45]
M-PEG-OA ≥90% Methoxy PEG OA mPEG Oleic Acid lipid for liposome formation.
Linear mPEG Hydroxyl Raw Materials
PEG RAW MATERIAL MAIN PEAK FRACTION BY GPC  POLYDISPERSITY BY GPC
M-PEG MW 5000, 10kDa, 20kDa, 30kDa, 40kDa ≥95% ≤ 1.05-1.10
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Founded in 2001 by recognized experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to on-site manufacturing from ethylene oxide, enabling facile traceability for GMP regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.