JenKem Technology’s patented products, “Y-shaped PEG” derivatives, also known as branched PEG derivatives, contain two linear methoxy PEG chains attached to a central active core. The sterically bulky structure of these “Y-shaped” PEG derivatives facilitates the single point attachment of a molecule. JenKem Technology provides branched PEG derivatives for amine pegylation (Y-NHS-40K), thiol pegylation (Y-MAL-40K), and N-terminal PEGylation (Y-AALD-40K and Y-PALD-40K) . JenKem’s “Y-shaped PEG” derivatives are chemically purified during synthesis and are essentially free of activated bifunctional PEG side products. The typical structure of “Y-shaped” branched PEG is as the following:
JenKem Technology Y-Shaped PEGs with molecular weights and functional groups not listed in our online catalog, may be available by custom synthesis. Please inquire at email@example.com about pricing and availability.
|Y-NHS-40K||≥95%||Y-shaped NHS PEG ester. Reactive PEG for the amino group of lysine(s), or N-terminal amine ; reaction completed in ≤1hr at pH 7-8|
|Y-COOH-40K||≥95%||Y-shaped Carboxyl PEG suitable for amine PEGylation|
|Y-MAL-40K||≥95%||Y-shaped Maleimide PEG. Thiol reactive PEG [3, 4] ; reacts at pH 5.0-6.5|
|Y-AALD-40K||≥95%||Y-shaped Acetaldehyde PEG N-terminal amine reactive PEG in the presence of a reducing reagent; less reactive but more selective compared to linear PEG aldehydes; reacts at pH 5-8|
|Y-PALD-40K||≥95%||Y-shaped Propion Aldehyde PEG. Reactive PEG for N-terminal amine in the presence of a reducing reagent; less selective but more reactive compared with Y-AALD-40K; reacts at pH 5-8|
|Y-NH2-40K||≥95%||Y-shaped Amine PEG, more reactive towards acylating agents than the hydroxyl group; readily undergoes reductive amination reactions |
|Y-FITC-40K||≥90%||Y-shape Fluorescein PEG, suitable for fluorescence monitoring of the PEGylation reaction with Y-shaped PEGs|
|Y-ALKYNE-40K||≥95%||Y-shaped Alkyne PEG is a convenient click PEG reagent for reaction with azide groups|
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