Methoxy Polyethylene Glycol Polylactide Block Copolymer

Description

JenKem Technology manufactures Methoxy PEG Polylactide Block Copolymers (Methoxy PEG PLA or Methoxy PLA PEG) from laboratory scale through GMP commercial scale. Methoxy Polyethylene Glycol Polylactide Block Copolymer are biodegradable copolymers employed in controlled release applications and in degradable medical devices.

MPEG5000-b-PLA2500 (Methoxy Polyethylene Glycol Polylactide Block Copolymer, PEG MW 5000, PLA MW 2500) and MPEG5000-b-PLA5000 (Methoxy Polyethylene Glycol Polylactide Block Copolymer, PEG MW 5000, PLA MW 5000) have a superior quality specification of ≥95% Purity.

Different MW combinations and reactive groups may be available. Please contact us for information on price and lead time.

References:

1. Su, T., et al., Ionizable polymeric nanocarriers for the codelivery of bi-adjuvant and neoantigens in combination tumor immunotherapy, Bioactive Materials, V. 26, 2023.
2. Nguyen, F., et al., Enhanced Intratumoral Delivery of SN38 as a Tocopherol Oxyacetate Prodrug Using Nanoparticles in a Neuroblastoma Xenograft Model, Clinical Cancer Research, 2018, pp.3811.
3. Jin, Q., et al., Edaravone-Encapsulated Agonistic Micelles Rescue Ischemic Brain Tissue by Tuning Blood-Brain Barrier Permeability, Theranostics, 2017, 7(4):884.
4. Hao, Y., et al., The evaluation of cellular uptake efficiency and tumor-target ability of MPEG-PDLLA micelles: Effect of particle size. RSC Advances, 2016, 17.
5. Liang, H., et al., Size-Shifting Micelle Nanoclusters Based on a Cross-Linked and pH-Sensitive Framework for Enhanced Tumor Targeting and Deep Penetration Features. ACS applied materials & interfaces. 2016, 8(16):10136-46.

Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.