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Branched PEG Derivatives
 
Branched PEG derivatives, also known as "Y-shaped" PEG derivatives, contain two linear methoxy PEG chain attached to a central core. The sterically bulky structure of these "Y-shaped" PEG derivatives will facilitate the single point attachment of the modified molecules.

 

The typical structure of "Y-shaped" branched PEG is as the following:

 

                                                    

JenKem Technology provides the following three kinds of "Y-shape" PEG derivatives. They are all JenKem's patented products. Y-NHS-40K can be used for amine PEGylation, Y-MAL-40K can be used for thiol PEGylation, and Y-ALD-40K (Y-AALD-40K and Y-PALD-40K) can be used for N-terminal PEGylation.

JenKem's "Y-shaped" PEG derivatives are chemically purified during synthesis so that they are low in polydispersity and are essentially free of activated bifunctional PEG side products.

 

List of Branched PEG Derivatives:

 

 

Y-NHS-40K: Y-shape PEG NHS Ester, MW 40001

Y-COOH-40K: Y-shape PEG Carboxyl, MW 400002

Y-MAL-40K: Y-shape PEG Maleimide, MW 400002

Y-AALD-40K: Y-shape PEG Acetaldehyde, MW 400003

Y-PALD-40K: Y-shape PEG Propionaldehyde, MW 400003

Y-NH2-40K: Y-shape PEG Amine, MW 400003

Y-FITC-40K: Y-shape PEG Fluorescein, MW 40000

 

4

 

 

 

For Amine PEGylation



 

Y-NHS-40K: Y-shape PEG NHS Ester, MW 40000

 

This "Y-shape" NHS ester will react with the amino group of lysine(s) or the N-terminal amine in biological active molecules to produce a stable amide linkage(s). This NHS ester will couple with the targeted molecules at pH 7-8. The PEGylation reaction can be finished in about 1 hour.

 

Average molecular weight of Y-NHS-40K is 40,000 Da. Substitution is 95% or greater. This product is basically free of activated bifunctional PEG side products.

 

 

ITEM CODE

ITEM NUMBER

ITEM DESCRIPTION

PRICE (USD)

A0001-1

Y-NHS-40K,1g

Y-shape PEG NHS Ester, MW 40000

$150

A0001-10

Y-NHS-40K,10g

Y-shape PEG NHS Ester, MW 40000

$1200

 

 

Y-COOH-40K: Y-shape PEG Carboxyl, MW 40000

 

Y-COOH-40K is the precursor to make Y-NHS-40K. Y-COOH is chromatographically purified with purity of 95% or greater.

 

ITEM CODE

ITEM NUMBER

ITEM DESCRIPTION

PRICE (USD)

A0019-1

Y-COOH-40K,1g

Y-shape PEG Carboxyl, MW 40000

$130

A0019-10

Y-COOH-40K,10g

Y-shape PEG Carboxyl, MW 40000

$1040

 

 

 

For Thiol PEGylation


 

 

Y-MAL-40K: Y-shape PEG Maleimide, MW 40000

 

This "Y-shape" PEG maleimide will react with the thiol groups in biological active molecules to generate a stable 3-thiosuccinimidyl ether linkage. “Y-shape” PEG maleimide will couple with the targeted molecules at pH 5.0-6.5 in the presence of other functional groups.

 

Average molecular weight of Y-MAL-40K is 40,000 Da. Substitution is 95% or greater. This product is basically free of activated bifunctional PEG side products.

 

 

ITEM CODE

ITEM NUMBER

ITEM DESCRIPTION

PRICE (USD)

A0002-1

Y-MAL-40K,1g

Y-shape PEG Maleimide, MW 40000

$180

A0002-10

Y-MAL-40K,10g

Y-shape PEG Maleimide, MW 40000

$1440

 

 

 

 

For N-Terminal PEGylation


The "Y-shape" PEG aldehyde will preferably react with the N-terminal amine in biological active molecules to produce a stable amine linkage in the presence of a reducing reagent such as sodium cyanoborohydride. "Y-shape" PEG aldehyde will couple with the N-terminal amine of the targeted molecules at pH 5-8.

 

Average molecular weight of "Y-shape" PEG aldehyde is 40,000 Da. Substitution is 95% or greater. This product is basically free of activated bifunctional PEG side products.

 

Compare with linear PEG aldehyde, Y-shape PEG aldehyde is less reactive but more selective.

We now provide the following two kinds of Y-shape PEG Aldehyde.

 

Y-AALD-40K: Y-shape PEG Acetaldehyde, MW 40000

Y-AALD-40K is more selective but less reactive compared with Y-PALD-40K.

 

 

ITEM CODE

ITEM NUMBER

ITEM DESCRIPTION

PRICE (USD)

A0003-1

Y-AALD-40K,1g

Y-shape PEG Acetaldehyde, MW 40000

$180

A0003-10

Y-AALD-40K,10g

Y-shape PEG Acetaldehyde, MW 40000

$1440

 

 

Y-PALD-40K: Y-shape PEG Propionaldehyde, MW 40000

Y-PALD-40K is a great branched PEG aldehyde with relatively good reactivity and selectivity. 

 

 

ITEM CODE

ITEM NUMBER

ITEM DESCRIPTION

PRICE (USD)

A0017-1

Y-PALD-40K,1g

Y-shape PEG Propionaldehyde, MW 40000

$180

A0017-10

Y-PALD-40K,10g

Y-shape PEG Propionaldehyde, MW 40000

$1440

 

 

 

Other Y-shaped PEG products


 

 

Y-NH2-40K: Y-shape PEG Amine, MW 40000

 

Y-NH2-40K is a Y-shaped PEG with primary amine group at the termini. The amine end group is more reactive toward acylating agents than the hydroxyl group. The amine group is also readily undergo reductive amination reactions. The substitution of Y-NH2-40K is 95% or greater.

 

 

ITEM CODE

ITEM NUMBER

ITEM DESCRIPTION

PRICE (USD)

A0010-1

Y-NH2-40K,1g

Y-shape PEG Amine, MW 40000

$180

A0010-10

Y-NH2-40K,10g

Y-shape PEG Amine, MW 40000

$1440

 

 

Y-FITC-40K: Y-shape PEG Fluorescein, MW 40000

 

The substitution of Y-FITC-40K is 90% or greater.

 

ITEM CODE

ITEM NUMBER

ITEM DESCRIPTION

PRICE (USD)

A0014-1

Y-FITC-40K,1g

Y-shape PEG Fluorescein, MW 40000

$250

A0014-10

Y-FITC-40K,10g

Y-shape PEG Fluorescein, MW 40000

$2,000

 

 

 

 

Please check our 2013 PEG Products Catalog

2013 Complete Product Catalog

 

Storage and Handling Conditions for PEGs and PEG Derivatives

 

To Place an Order:

 

Tel: 1-866-953-6536 (866.9JENKEM)

Tel: 1-972-673-0603

Fax: 1-469-327-2615

Email: sales@jenkemusa.com

 

Custom Synthesis

 

We have the capability of providing many PEG compounds that are not listed in this catalog and invite your custom synthesis inquiries. Please call or E-mail us at tech@jenkemusa.com to discuss or request a quote for any custom synthesis services. Strict confidentiality can be arranged if needed.

 

Technical and Customer Support

 

We have a Technical Support Team ready to help answer any of your questions. Please do not hesitate to contact them at tech@jenkemusa.com.

 

Bulk Orders and Commercial Manufacture

 

Larger than catalog, bulk orders up through commercial scale manufacturing can be supplied at a substantial discount. Both non-GMP and GMP quality PEG products can be provided. Please contact us at tech@jenkemusa.com for quotations on these types of orders.